Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach

1988 • 19,163 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

DNA methylation profiling of human chromosomes 6, 20 and 22

2006 • 1,308 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 • 1,118 citations

Quantification on the LightCycler

2001 • 885 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients

1997 • 757 citations

Regulatory T cells in cancer

2006 • 717 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3⁺ conventional T cells

2007 • 658 citations

Rapid Cycle Real-Time PCR: Methods and Applications

2001 • 640 citations

Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma

2005 • 618 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

2005 • 602 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers.

2003 • 487 citations

DNA Methylation Biomarkers for Blood-Based Colorectal Cancer Screening

2007 • 479 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

2003 • 474 citations

CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients

2006 • 416 citations

Tumor infiltrating Foxp3⁺ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

2006 • 410 citations

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

2007 • 384 citations

A Modified and Improved Method for Bisulphite Based Cytosine Methylation Analysis

1996 • 378 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

2006 • 213 citations

ANTIBODIES AGAINST FUNCTIONAL LEUKOCYTE SURFACE MOLECULES IN POLYCLONAL ANTILYMPHOCYTE AND ANTITHYMOCYTE GLOBULINS

1991 • 203 citations

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

2007 • 171 citations

FOXP3: Not just for regulatory T cells anymore

2006 • 165 citations

Foxp3 Expressing CD4+ CD25+ and CD8+CD28− T Regulatory Cells in the Peripheral Blood of Patients with Lung Cancer and Pleural Mesothelioma

2006 • 162 citations

CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases

2007 • 154 citations

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer

2006 • 122 citations

Everolimus and Basiliximab Permit Suppression by Human CD4+CD25+ Cells in vitro

2005 • 94 citations

CD4+CD25+ T regulatory cells in murine pregnancy

2005 • 82 citations

Effects of the Administration of High-Dose Interleukin-2 on Immunoregulatory Cell Subsets in Patients with Advanced Melanoma and Renal Cell Cancer

2007 • 75 citations

DNA Methylation Analysis as a Tool for Cell Typing

2006 • 68 citations

Addition of Histamine to Interleukin 2 Treatment Augments Type 1 T-Cell Responses in Patients with Melanoma In vivo: Immunologic Results from a Randomized Clinical Trial of Interleukin 2 with or without Histamine (MP 104)

2005 • 35 citations

Effect of Anti‐IL‐2Rα Antibody on IL‐2‐induced Jak/STAT Signaling

2002 • 32 citations

Article on High-Dose Interleukin-2 in Patients with Advanced Melanoma and Renal Cell Cancer

2007 • 9 citations

Addition of Histamine to IL-2 Treatment Augments T1 Cell-Funktion in Melanoma Patients In Vivo: Results from a Randomized Clinical Trial of IL-2 with or without Histamine (MP 104)

2004 • 3 citations