Tumor-Infiltrating Foxp3−CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Cancer Statistics, 2006

2006 • 5,351 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

The Heidelberg classification of renal cell tumours

1997 • 1,328 citations

An Outcome Prediction Model for Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy Based on Tumor Stage, Size, Grade and Necrosis: The Ssign Score

2002 • 1,073 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation

2000 • 1,029 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Classification of renal cell carcinoma

1997 • 887 citations

Infectious immunological tolerance.

1971 • 811 citations

Regulatory T cells and mechanisms of immune system control

2004 • 809 citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

2004 • 742 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.

2001 • 625 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

SYSTEMIC THERAPY FOR RENAL CELL CARCINOMA

2000 • 610 citations

Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

2003 • 525 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

2004 • 482 citations

Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

2005 • 453 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness

2005 • 259 citations

Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses

2004 • 239 citations

Regulatory T cells: Development, function and role in autoimmunity

2005 • 222 citations

CD4+ regulatory T cells: Mechanisms of induction and effector function

2005 • 205 citations

Improved treatment response with basiliximab immunoprophylaxis after liver transplantation: Results from a double-blind randomized placebo-controlled trial

2002 • 185 citations

Interleukin-6, Interleukin-10, and Vascular Endothelial Growth Factor in Metastatic Renal Cell Carcinoma: Prognostic Value of Interleukin-6—From the Groupe Français d'Immunothérapie

2004 • 173 citations

The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer

2003 • 153 citations

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

2005 • 146 citations

Comparison of Standardized and Nonstandardized Nuclear Grade of Renal Cell Carcinoma to Predict Outcome Among 2,042 Patients

2002 • 139 citations

Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipient. Inhibition by suppressor T cells.

1983 • 123 citations

CD4 regulatory T cells in human cancer pathogenesis

2006 • 117 citations

Mononuclear cell infiltration in clear‐cell renal cell carcinoma independently predicts patient survival

2006 • 73 citations

Immunotherapy of Renal Cell Carcinoma

1991 • 60 citations

IL-4 inhibits the TNF-α induced proliferation of renal cell carcinoma (RCC) and cooperates with TNF-α to induce apoptotic and cytokine responses by RCC: implications for antitumor immune responses

2006 • 35 citations

Improvement strategies for molecular targeting: cyclooxygenase-2 inhibitors as radiosensitizers for non-small cell lung cancer

2004 • 34 citations

Allogeneic stem cell transplantation as immunotherapy for nonhematological cancers

2004 • 24 citations

Basiliximab reduces acute liver allograft rejection in pediatric patients

2002 • 22 citations

Effects of tumor necrosis factor α in renal cell carcinoma

2003 • 12 citations

Strong-Arming Immune Regulation: Suppressing Regulatory T-Cell Function To Treat Cancers

2006 • 8 citations

Cited By (0)

Loading...