Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

2007 • 1,102 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24

2007 • 872 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

A common variant associated with prostate cancer in European and African populations

2006 • 784 citations

Evidence for a prostate cancer susceptibility locus on the X chromosome.

1998 • 682 citations

Multiple regions within 8q24 independently affect risk for prostate cancer

2007 • 659 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

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Myc deletion rescues Apc deficiency in the small intestine

2007 • 587 citations

Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee

2004 • 582 citations

Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

1998 • 453 citations

Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization.

1997 • 443 citations

KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

2001 • 426 citations

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

2007 • 384 citations

Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation

2001 • 373 citations

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

2008 • 372 citations

A common genetic risk factor for colorectal and prostate cancer

2007 • 369 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Transcriptional activation of the translocated c- myc oncogene in Burkitt lymphoma

1983 • 340 citations

An X Chromosome Gene, WTX , Is Commonly Inactivated in Wilms Tumor

2007 • 330 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

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Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination.

1992 • 291 citations

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

1995 • 289 citations

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.

1996 • 254 citations

Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung

1986 • 253 citations

Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay.

1999 • 251 citations

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

2007 • 242 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Evidence of an X-linked or recessive genetic component to prostate cancer risk

1995 • 232 citations

A Germline DNA Polymorphism Enhances Alternative Splicing of the KLF6 Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

2005 • 212 citations

Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia.

1986 • 205 citations

X-Chromosome Genetics and Human Cancer

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Prostatic Intraepithelial Neoplasia in Genetically Engineered Mice

2002 • 170 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Cutting Edge: Broad Expression of the FoxP3 Locus in Epithelial Cells: A Caution against Early Interpretation of Fatal Inflammatory Diseases following In Vivo Depletion of FoxP3-Expressing Cells

2008 • 118 citations

Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics

1990 • 111 citations

FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus

2009 • 96 citations

htert expression correlates with MYC over-expression in human prostate cancer

2000 • 92 citations

Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein

2000 • 77 citations

htert expression correlates withMYC over-expression in human prostate cancer

2000 • 69 citations

INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION

2006 • 63 citations

Evidence for a Prostate Cancer Susceptibility Locus on the X Chromosome

1999 • 45 citations

Cancer genetics: Tumor suppressor meets oncogene

1999 • 35 citations

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia‐inducible factor (HIF)‐2α but not HIF‐1α

2007 • 28 citations

Mutation screening and association study of the candidate prostate cancer susceptibility genesMSR1,PTEN, andKLF6

2006 • 27 citations

Role of c-Myc in Apc Mutant Intestinal Phenotype: Case Closed or Time for a New Beginning?

2007 • 11 citations