X-Chromosome Genetics and Human Cancer

A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis

1949 • 1,000 citations

Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development

2003 • 797 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

Chromosomal silencing and localization are mediated by different domains of Xist RNA

2002 • 716 citations

Evidence for a prostate cancer susceptibility locus on the X chromosome.

1998 • 682 citations

The DNA methylation paradox

1999 • 642 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

Xist RNA and the Mechanism of X Chromosome Inactivation

2002 • 438 citations

Linking the epigenetic ‘language’ of covalent histone modifications to cancer

2004 • 385 citations

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes

2001 • 369 citations

Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos

2003 • 365 citations

A first-generation X-inactivation profile of the human X chromosome

1999 • 362 citations

Age- and tissue-specific variation of X chromosome inactivation ratios in normal women

2000 • 330 citations

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

2002 • 302 citations

A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation

1997 • 290 citations

Gene Expression Profiles of BRCA1-Linked, BRCA2-Linked, and Sporadic Ovarian Cancers

2002 • 284 citations

Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours

2000 • 272 citations

Chromosomal Imbalances in Papillary Renal Cell Carcinoma

1998 • 232 citations

Evidence of an X-linked or recessive genetic component to prostate cancer risk

1995 • 232 citations

Glypican-3 expression is silenced in human breast cancer

2001 • 201 citations

Sex-Specific Expression of Gastrin-Releasing Peptide Receptor: Relationship to Smoking History and Risk of Lung Cancer

2000 • 190 citations

Pathogenesis of testicular germ cell tumours

1999 • 190 citations

Senescence of Nickel-Transformed Cells by an X Chromosome: Possible Epigenetic Control

1991 • 188 citations

Frequent silencing of the GPC3 gene in ovarian cancer cell lines.

1999 • 173 citations

Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.

1999 • 167 citations

Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma

2000 • 155 citations

Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.

2000 • 153 citations

Recruitment and Spreading of the C. elegans Dosage Compensation Complex Along X Chromosomes

2004 • 131 citations

The Spreading of X Inactivation into Autosomal Material of an X;autosome Translocation: Evidence for a Difference between Autosomal and X-Chromosomal DNA

1998 • 130 citations

Association Between Nonrandom X-Chromosome Inactivation and BRCA1 Mutation in Germline DNA of Patients With Ovarian Cancer

1999 • 124 citations

XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer

2004 • 119 citations

Cytosine methylation mediates sexual conflict

2003 • 114 citations

Cytogenetics of a renal cell carcinoma in a 17-month-old child

1991 • 112 citations

Simpson‐golabi‐behmel syndrome associated with renal dysplasia and embryonal tumor: Localization of the gene to Xqcen‐q21

1992 • 108 citations

X-Linked Wiskott–Aldrich Syndrome in a Girl

1998 • 108 citations

Selection against mutant alleles in blood leukocytes is a consistent feature in Incontinentia Pigmenti type 2

1996 • 105 citations

Molecular and cytogenetic analysis of the spreading of X inactivation in X;autosome translocations

2002 • 99 citations

X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status.

1997 • 97 citations

Comparison of loss of heterozygosity patterns in invasive low-grade and high-grade epithelial ovarian carcinomas.

1993 • 97 citations

Evidence of skewed X-chromosome inactivation in 47,XXY and 48,XXYY Klinefelter patients

2000 • 96 citations

Carcinoma of the Male Breast And Klinefelter's Syndrome: Is There an Association?

1987 • 94 citations

Sensitive detection of chromosome copy number aberrations in prostate cancer by fluorescence in situ hybridization.

1994 • 89 citations

Promoter-specific hypoacetylation of X-inactivated genes

1999 • 87 citations

The Roles of Supernumerical X Chromosomes and XIST Expression in Testicular Germ Cell Tumors

2003 • 86 citations

High frequency of skewed X inactivation in young breast cancer patients

2002 • 83 citations

Potential Role of the Inactivated X Chromosome in Ovarian Epithelial Tumor Development

1996 • 80 citations

Frequent loss of heterozygosity on chromosomes Xp and 13q in human ovarian cancer

1992 • 76 citations

The XAGE family of cancer/testis‐associated genes: Alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma

2002 • 73 citations

X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications

2001 • 68 citations

Evidence for a correlation between late replication and autosomal gene inactivation in a familial translocation t(X;21)

1979 • 66 citations

Gastric neuroendocrine neoplasms: tumour clonality and malignancy-associated large X-chromosomal deletions

1999 • 63 citations

Localisation of susceptibility genes for familial testicular germ cell tumour

2003 • 59 citations

Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin

2002 • 58 citations

Hypomethylated X Chromosome Gain and Rare Isochromosome 12p in Diverse Intracranial Germ Cell Tumors

2002 • 57 citations

Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy.

1995 • 50 citations

Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas

1997 • 49 citations

Analysis of loss of heterozygosity andKRAS2 mutations in ovarian neoplasms: Clinicopathological correlations

1997 • 48 citations

Identification of novel deletion regions on chromosome arms 2q and 6p in breast carcinomas by amplotype analysis

2001 • 48 citations

Malignancy‐associated allelic losses on the X‐chromosome in foregut but not in midgut endocrine tumours

2002 • 47 citations

Imbalance of sex chromosomes, with gain of early‐replicating X, in human solid tumors

1986 • 44 citations

Androgen receptor gene alterations and chromosomal gains and losses in prostate carcinomas appearing during finasteride treatment for benign prostatic hyperplasia.

1999 • 43 citations

A one centimorgan deletion unit on chromosome Xq12 is commonly lost in borderline and invasive epithelial ovarian tumors

1998 • 42 citations

Comparative genomic hybridization analysis of hepatoblastoma reveals high frequency of X-chromosome gains and similarities between epithelial and stromal components

2003 • 38 citations

Lack of expression of XIST from a small ring X chromosome containing the XIST locus in a girl with short stature, facial dysmorphism and developmental delay

2002 • 36 citations

PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration

2003 • 36 citations

Growth and Ovarian Function in Girls with 48,XXXX Karyotype - Patient Report and Review of the Literature

2002 • 34 citations

Chromosomes, sex chromatin, and cancer.

1957 • 34 citations

A conserved region in human and Chinese hamster X chromosomes can induce cellular senescence of nickel-transformed Chinese hamster cell lines

1992 • 33 citations

Confirmation of the prostate cancer susceptibility locus HPCX in a set of 104 German prostate cancer families

2002 • 32 citations

Frequent loss Xq25 on the inactive X chromosome in primary breast carcinomas is associated with tumor grade and axillary lymph node metastasis

2001 • 30 citations

A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved

2002 • 29 citations

Two identical active X chromosomes in human mammary carcinoma cells

1990 • 25 citations

Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression☆

2003 • 23 citations

XX MALE: A RARE CAUSE OF SHORT STATURE, INFERTILITY, GYNAECOMASTIA AND CARCINOMA OF THE BREAST

2003 • 22 citations

Acquired gain of an X chromosome as the sole abnormality in the blast crisis of chronic neutrophilic leukemia

2002 • 22 citations

Acquired X-chromosome aneuploidy in children with acute lymphoblastic leukemia

1999 • 21 citations

Analysis of methylation of a human X located gene which escapes X inactivation

1988 • 20 citations

Xp22.2-3 Loss of Heterozygosity Is Associated with Germline BRCA1 Mutation in Ovarian Cancer

2000 • 19 citations

Karyotypic Findings in Two Cases of Male Breast Cancer

2000 • 17 citations

XX Male with breast cancer

1980 • 15 citations

Xq27–28 deletions in prostate carcinoma

2003 • 15 citations

SEX CHROMATIN IN CELLS OF PROSTATIC HYPERTROPHY AND PROSTATIC CANCER

1956 • 14 citations

Sex chromosomes in a series of 79 colorectal cancers: Replication pattern, numerical, and structural changes

1990 • 13 citations

Absence of Late-Replicating X-Chromosome in a Female Patient With Acute Myeloid Leukemia and the 8;21 Translocation<xref ref-type="fn" rid="fn2">2</xref>

1979 • 12 citations

A t(X;15)(q23;q25) with Xq reactivation in a lymphoblastoid cell line from Fanconi anemia

1991 • 7 citations

RESPONSE: Re: Association Between Nonrandom X-Chromosome Inactivation and BRCA1 Mutation in Germline DNA of Patients With Ovarian Cancer

1999 • 5 citations

Incontinentia Pigmenti: The First Single Gene Disorder Due to Disrupted NF-kappaB Function

2002 • 1 citations

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