Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6

The language of covalent histone modifications

2000 • 8,260 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

2000 • 1,245 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Regulation of Transcription by a Protein Methyltransferase

1999 • 1,169 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1999 • 1,065 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

Cytokines in acute and chronic inflammation

1997 • 930 citations

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

2000 • 867 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

1997 • 714 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China

1998 • 619 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1998 • 587 citations

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

1998 • 578 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

1996 • 571 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 • 563 citations

Eukaryotic Transcription: An Interlaced Network of Transcription Factors and Chromatin-Modifying Machines

1998 • 561 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

p38 MAPK signalling cascades in inflammatory disease

1999 • 552 citations

The Enhanceosome and Transcriptional Synergy

1998 • 545 citations

Chromatin disruption and modification

1999 • 537 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

Multiple signals converging on NF-κB

1999 • 483 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

1997 • 482 citations

Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3

1999 • 478 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65

1998 • 462 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

1999 • 444 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

1998 • 433 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

2000 • 424 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

The IKK complex: an integrator of all signals that activate NF-κB?

2000 • 400 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

The IκB/NF-κB system: a key determinant of mucosal inflammation and protection

2000 • 377 citations

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks

2000 • 377 citations

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

1997 • 376 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation

1997 • 371 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1997 • 355 citations

The Nuclear Factor-κB Engages CBP/p300 and Histone Acetyltransferase Activity for Transcriptional Activation of the Interleukin-6 Gene Promoter

1999 • 354 citations

Initiation of acute phase response and synthesis of cytokines

1996 • 338 citations

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

1997 • 337 citations

Role of NF-κB in immune and inflammatory responses in the gut

1998 • 335 citations

NF- κ B and the innate immune response

2000 • 332 citations

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

1998 • 330 citations

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF‐κB

1997 • 325 citations

Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

1994 • 325 citations

Transcription factors and asthma

1998 • 324 citations

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

2000 • 323 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

2000 • 319 citations

The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators

1999 • 314 citations

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

1998 • 307 citations

Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy

1998 • 306 citations

Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma.

1999 • 302 citations

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

1999 • 301 citations

Ikappa Balpha -independent downregulation of NF-kappa B activity by glucocorticoid receptor

1997 • 298 citations

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A

1998 • 298 citations

p300 gene alterations in colorectal and gastric carcinomas.

1996 • 293 citations

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

1999 • 289 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

Histone acetylation and cancer

1999 • 261 citations

Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

2000 • 259 citations

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

1998 • 257 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

CREB-binding protein and p300: molecular integrators of hematopoietic transcription

2000 • 254 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations

1998 • 232 citations

Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation

1998 • 230 citations

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

1999 • 226 citations

Sequential DNA damage-independent and -dependent activation of NF-kappa B by UV

1998 • 225 citations

A Dual Mechanism Mediates Repression of NF-κB Activity by Glucocorticoids

1998 • 225 citations

Reactive Oxygen Intermediate-Dependent NF-κB Activation by Interleukin-1β Requires 5-Lipoxygenase or NADPH Oxidase Activity

1999 • 224 citations

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition.

1999 • 217 citations

Chromatin-modifying and -remodeling complexes

1999 • 217 citations

TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105

1999 • 214 citations

Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors

1995 • 213 citations

Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway

1999 • 211 citations

Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity

1999 • 209 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

1996 • 204 citations

NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes

1999 • 204 citations

Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways

2000 • 197 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling

1999 • 192 citations

Activation of nuclear factor ?B in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis

2000 • 188 citations

Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription

1999 • 184 citations

The development and therapeutic potential of protein kinase inhibitors

1999 • 184 citations

Histone acetyltransferases regulate HIV-1 enhancer activity in vitro

1997 • 183 citations

Nuclear factor-κB/Rel proteins

1999 • 180 citations

N-Acetyl-<scp>l</scp>-Cysteine Inhibits Primary Human T Cell Responses at the Dendritic Cell Level: Association with NF-κB Inhibition

1999 • 179 citations

Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways

2000 • 175 citations

JIL-1

1999 • 168 citations

Interaction of the COOH-terminal Transactivation Domain of p65 NF-κB with TATA-binding Protein, Transcription Factor IIB, and Coactivators

1995 • 157 citations

Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho

1997 • 157 citations

RNA polymerase II as a control panel for multiple coactivator complexes

1999 • 155 citations

Analysis of an Activator:Coactivator Complex Reveals an Essential Role for Secondary Structure in Transcriptional Activation

1998 • 155 citations

Activation Domain-Specific and General Transcription Stimulation by Native Histone Acetyltransferase Complexes

1999 • 155 citations

The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

1996 • 152 citations

Gene activation by histone and factor acetyltransferases

1999 • 152 citations

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300

1998 • 141 citations

Recombination Signal Sequence Binding Protein Jκ Is Constitutively Bound to the NF-κB Site of the Interleukin-6 Promoter and Acts as a Negative Regulatory Factor

1997 • 140 citations

De Wilde V.

1986 • 135 citations

Regulation of P21cip1 Expression by Growth Factors and the Extracellular Matrix Reveals a Role for Transient ERK Activity in G1 Phase

1999 • 135 citations

Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter

1998 • 134 citations

Modifying chromatin and concepts of cancer

1999 • 131 citations

Drosophila CBP is required for dorsal–dependent twist gene expression

1997 • 118 citations

HIV-1 Tat Induces the Expression of the Interleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting with CAAT Enhancer-binding Protein β (NF-IL6) Transcription Factors

1997 • 116 citations

Dorsal-Mediated Repression Requires the Formation of a Multiprotein Repression Complex at the Ventral Silencer

1998 • 114 citations

Innovative treatment programs against cancer

1999 • 114 citations

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism.

1999 • 112 citations

The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness

1999 • 108 citations

Chromatin remodeling: a marriage between two families?

1998 • 108 citations

The Phosphorylation Status of a Cyclic AMP-Responsive Activator Is Modulated via a Chromatin-Dependent Mechanism

2000 • 107 citations

Factor-specific modulation of CREB-binding protein acetyltransferase activity

1999 • 105 citations

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

1995 • 102 citations

Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

1999 • 101 citations

Novel Approaches and Targets for Treatment of Chronic Obstructive Pulmonary Disease

1999 • 98 citations

Nerve Growth Factor Up-regulates the Transcriptional Activity of CBP through Activation of the p42/p44MAPK Cascade

1998 • 97 citations

Chromatin interaction mechanism of transcriptional control invivo

1998 • 95 citations

The PCAF acetylase complex as a potential tumor suppressor

2000 • 90 citations

Inhibition of Nuclear Factor-κB-mediated Transcription by Association with the Amino-terminal Enhancer of Split, a Groucho-related Protein Lacking WD40 Repeats

2000 • 88 citations

TAFII105 mediates activation of anti-apoptotic genes by NF-kappa B

1998 • 81 citations

Characterization of an E1A-CBP Interaction Defines a Novel Transcriptional Adapter Motif (TRAM) in CBP/p300

1999 • 79 citations

A Weak TATA Box Is a Prerequisite for Glucocorticoid-dependent Repression of the Osteocalcin Gene

1997 • 79 citations

Chromium(VI) Inhibits the Transcriptional Activity of Nuclear Factor-κB by Decreasing the Interaction of p65 with cAMP-responsive Element-binding Protein-binding Protein

1999 • 77 citations

Cross-talk between steroids and NF-κB: what language?

1998 • 77 citations

New targets for anti-inflammatory drugs

1999 • 73 citations

Long-range transcriptional regulation of cytokine gene expression

1998 • 71 citations

Cell Cycle Regulation of the Transcriptional Coactivators p300 and CREB Binding Protein

1998 • 69 citations

TAF _II mutations disrupt Dorsal activation in the Drosophila embryo

1998 • 69 citations

Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects

1997 • 68 citations

Signaling by Tyrosine Kinases Negatively Regulates the Interaction between Transcription Factors and SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) Corepressor

1998 • 59 citations

Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2)

1999 • 59 citations

CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression

1999 • 57 citations

Disruption of Raf-1/Heat Shock Protein 90 Complex and Raf Signaling by Dexamethasone in Mast Cells

2000 • 56 citations

Tumor Necrosis Factor-α-dependent Activation of a RelA Homodimer in Astrocytes

1995 • 55 citations

CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment

1999 • 55 citations

Nuclear factor κB (NF-κB) pathway as a therapeutic target in rheumatoid arthritis

1999 • 54 citations

Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)

1999 • 54 citations

Chromatin and transcription

1998 • 51 citations

Hormone‐activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells

1999 • 51 citations

Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate

1999 • 50 citations

Activation of p42/p44 mitogen‐activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55‐kDa TNF receptor

1998 • 46 citations

NF-κB/Rel family members are physically associated phosphoproteins

1994 • 46 citations

Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells.

2000 • 45 citations

Organization of chromatin in cancer cells: role of signalling pathways

1999 • 43 citations

Cooperation between Phosphorylation and Acetylation Processes in Transcriptional Control

1999 • 40 citations

Pharmacological Modulation of Cytokine Action and Production through Signaling Pathways

1998 • 36 citations

NF-κB activation and HIV-1 induced apoptosis

1999 • 35 citations

Innovative treatment programs against cancer

1998 • 34 citations

A firm hand on NFκB: structures of the IκBα–NFκB complex

1999 • 34 citations

Organization of chromatin in cancer cells: role of signalling pathways

1999 • 30 citations

Histone acetylation in signal transduction by growth regulatory signals

1999 • 22 citations

Inactivation of p42 Mitogen-activated Protein Kinase Is Required for Exit from M-phase after Cyclin Destruction

1999 • 22 citations

Gene-regulating protein kinases as important anti-inflammatory targets

1999 • 20 citations

Activation of the nuclear factor κB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression

1993 • 19 citations

Mitogen-activated protein kinases enhance long-range activation by the β-globin locus control region

1998 • 16 citations

How Chromatin Changes Its Shape

1999 • 15 citations

Transcription: Common cofactors and cooperative recruitment

1999 • 9 citations

Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.

1994 • 7 citations

TNF-induced Mechanisms for IL6 Gene Induction

1995 • 4 citations

NF-κB as an emerging target in atopy

1999 • 3 citations