The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Transcriptional regulation

1991 • 893 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA

1995 • 718 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

1991 • 519 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Interferons and other regulatory cytokines

1989 • 306 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1994 • 283 citations

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

1990 • 249 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.

1991 • 175 citations

The IκB proteins: members of a multifunctional family

1993 • 169 citations

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

1993 • 168 citations

Structure and expression of a cloned cDNA for mouse interferon-beta.

1983 • 157 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene

1995 • 142 citations

Interferons as Gene Activators

1989 • 124 citations

Transcription factor interactions: basics on zippers

1991 • 124 citations

Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA

1976 • 111 citations

Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein

1995 • 110 citations

Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.

1987 • 98 citations

Postinduction Turnoff of Beta-Interferon Gene Expression

1990 • 96 citations

A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-? in myeloid cells

1992 • 87 citations

Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster.

1992 • 86 citations

Interferon Action: Cytoplasmic and Nuclear Localization of the Interferon-Inducible 52-kD Protein That Is Encoded by the Ifi 202 Gene from the Gene 200 Cluster

1993 • 81 citations

The interferon-activatable gene 200 cluster: from structure toward function

1995 • 67 citations

Interferons as gene activators: A cluster of six interferon-activatable genes is linked to the erythroid α-spectrin locus on murine chromosome 1

1989 • 58 citations

Cloning and expression of the human myeloid cell nuclear differentiation antigen: Regulation by interferon α

1992 • 58 citations

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

1995 • 56 citations

A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes

1993 • 44 citations

Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1

1989 • 43 citations

Impaired transcription of the poly rl:rC- and interferon-activatable 202 gene in mice and cell lines from the C57BU6 strain

1992 • 27 citations

In vitro transcription of immunoglobulin genes in a B-cell extract: effects of enhancer and promoter sequences.

1987 • 27 citations

DNA-binding domains: targets for viral and cellular regulators

1994 • 24 citations

Interferons

1990 • 12 citations