Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

1993 • 584 citations

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

1997 • 546 citations

Gene number, noise reduction and biological complexity

1995 • 462 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

DNA Methylation Specifies Chromosomal Localization of MeCP2

1996 • 343 citations

Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis

1997 • 320 citations

Somatic Mutations in Paroxysmal Nocturnal Hemoglobinuria: A Blessing in Disguise?

1997 • 305 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

Altered DNA methylation and genome instability: A new pathway to cancer?

1997 • 204 citations

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

1998 • 161 citations

Inactive chromatin spreads from a focus of methylation.

1993 • 124 citations

CpG methylation remodels chromatin structure in vitro

1997 • 101 citations

Nucleosome Assembly on Methylated CGG Triplet Repeats in the Fragile X Mental Retardation Gene 1 Promoter

1996 • 87 citations

Methylation of replicating and post-replicated mouse L-cell DNA.

1983 • 70 citations

Role of Chromatin and Xenopus laevis Heat Shock Transcription Factor in Regulation of Transcription from the X. laevis hsp70 Promoter In Vivo

1995 • 64 citations

Remodeling of regulatory nucleoprotein complexes on the Xenopus hsp70 promoter during meiotic maturation of the Xenopus oocyte

1997 • 30 citations