Nuclear factor-κB/Rel proteins

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

1997 • 1,005 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

1997 • 676 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.

1997 • 547 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

Inhibition of NF- B DNA Binding by Nitric Oxide

1996 • 479 citations

(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB

1997 • 452 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

1995 • 312 citations

Constitutive NF-kappa B activity in neurons.

1994 • 304 citations

Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1

1995 • 301 citations

Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.

1995 • 289 citations

Brain synapses contain inducible forms of the transcription factor NF-κB

1993 • 225 citations

Gene expression of the transcription factor NF-κ B in hippocampus: regulation by synaptic activity

1996 • 221 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats

1997 • 219 citations

Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease

1996 • 208 citations

Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum

1996 • 195 citations

Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor

1996 • 192 citations

Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α

1995 • 173 citations

Janus faces of NF-κB: Neurodestruction versus neuroprotection

1997 • 163 citations

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

1997 • 154 citations

Alteration of Transcription Factor Binding Activities in the Ischemic Rat-Brain

1995 • 153 citations

Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures

1996 • 152 citations

Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease

1997 • 151 citations

Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

1992 • 147 citations

Seizure Activity Results in a Rapid Induction of Nuclear Factor‐κB in Adult but Not Juvenile Rat Limbic Structures

1996 • 134 citations

Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis

1994 • 133 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids

1998 • 106 citations

Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia–telangiectasia

1997 • 102 citations

Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

1995 • 98 citations

Iron Chelation Decreases NF-kB and HIV Type 1 Activation due to Oxidative Stress

1995 • 95 citations

NF-kappa B activates the HIV promoter in neurons.

1993 • 85 citations

Increased cortical nuclear factor-κB (NF-κB) DNA binding activity after traumatic brain injury in rats

1995 • 82 citations

Regulation of NF-κB activity in rat dorsal root ganglia and PC12 cells by tumour necrosis factor and nerve growth factor

1995 • 78 citations

Presence of NF-κB-like and IκB-like immunoreactivities in postsynaptic densities

1997 • 56 citations

A μ-receptor opioid agonist induces AP-1 and NF-κB transcription factor activity in primary cultures of rat cortical neurons

1996 • 48 citations

Nuclear factor-κB in rat brain: Enhanced DNA-binding activity following convulsant-induced seizures

1994 • 45 citations

Stimulation of HIV Type 1 Gene Expression and Induction of NF-κB (p50/p65)-Binding Activity in Tumor Necrosis Factor α-Treated Human Fetal Glial Cells

1994 • 39 citations

Interferon regulatory factor-2 physically interacts with NF-κB in vitro and inhibits NF-κB induction of major histocompatibility class I and β2-microglobulin gene expression in transfected human neuroblastoma cells

1995 • 38 citations

Transcription of the JC virus archetype late genome: importance of the kappa B and the 23-base-pair motifs in late promoter activity in glial cells

1996 • 31 citations

Cytokine-modulating activity of tepoxalin, a new potential antirheumatic

1995 • 21 citations

Transcriptional pharmacology of neurodegenerative disorders: novel venue towards neuroprotection against excitotoxicity?

1997 • 18 citations