Activation of the nuclear factor κB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens

1984 • 655 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts

1986 • 343 citations

[Tumor necrosis factor].

1990 • 340 citations

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

1988 • 297 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

Interleukin-6 Induction by Tumor Necrosis Factor and Interleukin-1 in Human Fibroblasts Involves Activation of a Nuclear Factor Binding to a κΒ-Like Sequence

1990 • 269 citations

Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.

1990 • 189 citations

A Multiple Cytokine- and Second Messenger-Responsive Element in the Enhancer of the Human Interleukin-6 Gene: Similarities with c-fosGene Regulation

1989 • 178 citations

The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity.

1990 • 167 citations

Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding.

1990 • 132 citations

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

1987 • 121 citations

A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.

1989 • 116 citations

Tumor necrosis factor-alpha activation of the IL-2 receptor-alpha gene involves the induction of kappa B-specific DNA binding proteins.

1989 • 98 citations

Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.

1989 • 82 citations

The Biology of the Interferon System 1986

1987 • 81 citations

Interferon β2 as a promoter of growth and differentiation of B cells

1987 • 74 citations

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.

1992 • 71 citations

A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes.

1990 • 67 citations

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

1991 • 51 citations

TNF‐mediated IL6 gene expression and cytotoxicity are co‐inducible in TNF‐resistant L929 cells

1992 • 19 citations

Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells

1991 • 16 citations