Gene-regulating protein kinases as important anti-inflammatory targets

STATs and Gene Regulation

1997 • 3,927 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

A thousand and one protein kinases

1987 • 1,066 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

1998 • 792 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1997 • 274 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1998 • 191 citations

Pyrroles and other heterocycles as inhibitors of P38 kinase

1998 • 116 citations

The Intracellular Receptor and Signal Transducers and Activators of Transcription Factor Superfamilies: Novel Targets for Small-Molecule Drug Discovery

1995 • 77 citations

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

1998 • 75 citations

Phosphatidylinositol 3-kinase related kinases

1996 • 61 citations

Potent inhibitors of the MAP kinase p38

1998 • 43 citations