Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes

1980 • 1,256 citations

RNA recognition: towards identifying determinants of specificity

1991 • 739 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

1989 • 601 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes.

1991 • 182 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

Intranuclear localization of snRNP antigens.

1986 • 140 citations

Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin.

1991 • 104 citations

5′-terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matrices

1984 • 79 citations

Structure and Expression of the Drosophila melanogaster Gene for the U1 Small Nuclear Ribonucleoprotein Particle 70K Protein

1990 • 70 citations

Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K).

1988 • 59 citations