Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes

1980 • 1,256 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

Codon usage tabulated from the GenBank Genetic Sequence Data

1988 • 608 citations

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

1989 • 601 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

Sex in flies: the splice of life

1989 • 468 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Poly(A) signals

1991 • 438 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif

1989 • 395 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

Base pairing involving deoxyinosine: implications for probe design

1985 • 330 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

1991 • 303 citations

N-formylmethionyl-sRNA as the initiator of protein synthesis.

1966 • 296 citations

Evidence that approximately eighty per cent of the soluble proteins from Ehrlich ascites cells are Nalpha-acetylated.

1976 • 274 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Cloning of the human cDNA for the U1 RNA-associated 70K protein.

1986 • 235 citations

Suppression of the negative effect of minor arginine codons on gene expression; preferential usage of minor codons within the first 25 codons of theEscherichia coligenes

1990 • 226 citations

RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

1991 • 196 citations

Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif

1987 • 187 citations

On/off regulation of gene expression at the level of splicing

1988 • 186 citations

In vitro protein synthesis: chain initiation.

1966 • 166 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding

1987 • 148 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Codon usage tabulated from the GenBank genetic sequence data

1990 • 125 citations

Epidermodysplasia verruciformis-associated human papillomavirus 8: genomic sequence and comparative analysis

1986 • 123 citations

Nucleotide sequence and genome organization of human papillomavirus type 5

1987 • 105 citations

Precision and orderliness in splicing

1987 • 104 citations

Structure and Expression of the Drosophila melanogaster Gene for the U1 Small Nuclear Ribonucleoprotein Particle 70K Protein

1990 • 70 citations

Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K).

1988 • 59 citations

Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization.

1987 • 54 citations

Structure and expression of the Drosophila melanogaster gene for the U1 small nuclear ribonucleoprotein particle 70K protein.

1990 • 35 citations

A U1 Small Nuclear Ribonucleoprotein Particle with Altered Specificity Induces Alternative Splicing of an Adenovirus E1A mRNA Precursor

1989 • 22 citations

Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae.

1987 • 14 citations

A U1 small nuclear ribonucleoprotein particle with altered specificity induces alternative splicing of an adenovirus E1A mRNA precursor.

1989 • 9 citations