Splicing of pre-mRNA: mechanism, regulation and role in development

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

RNA recognition: towards identifying determinants of specificity

1991 • 739 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Cloning and domain structure of the mammalian splicing factor U2AF

1992 • 566 citations

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

1992 • 466 citations

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

1992 • 438 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1992 • 368 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Cloning and characterization of PSF, a novel pre-mRNA splicing factor.

1993 • 359 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome

1991 • 329 citations

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

1993 • 309 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

Modular organization of actin crosslinking proteins

1991 • 282 citations

More is better: Activators and repressors from the same gene

1992 • 280 citations

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

1992 • 273 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Isolation of a Complementary DNA that Encodes the Mammalian Splicing Factor SC35

1992 • 244 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript

1992 • 221 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function.

1991 • 217 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

Mutations in yeast U5 snRNA alter the specificity of 5′ splice-site cleavage

1991 • 202 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

1992 • 198 citations

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

1992 • 189 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast.

1992 • 161 citations

Who's on first? The U1 snRNP-5 splice site interaction and splicing

1991 • 156 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

The purified yeast pre-mRNA splicing factor PRP2 is an RNA-dependent NTPase.

1992 • 149 citations

Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.

1992 • 144 citations

Association of U6 snRNA with the 5'-splice site region of pre-mRNA in the spliceosome.

1992 • 143 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

Are vertebrate exons scanned during splice-site selection?

1992 • 141 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

Characterization of the major hnRNP proteins from Drosophila melanogaster.

1992 • 130 citations

Studies of the strand-annealing activity of mammalian hnRNP complex protein A1

1990 • 114 citations

mRNA splicing and autocatalytic introns: Distant cousins or the products of chemical determinism?

1993 • 112 citations

The spliceosome assembly pathway in mammalian extracts.

1992 • 111 citations

Mutations at the 3′ splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast

1992 • 109 citations

Splicing Takes a Holliday

1992 • 109 citations

Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns

1992 • 103 citations

Control ofDrosophila Sex-lethalpre-mRNA splicing by its own female-specific product

1992 • 100 citations

An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.

1993 • 98 citations

Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing.

1992 • 98 citations

Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain

1992 • 98 citations

Isolation of hnRNP complexes from Drosophila melanogaster.

1992 • 95 citations

Multiple Zinc Finger Forms Resulting from Developmentally Regulated Alternative Splicing of a Transcription Factor Gene

1992 • 94 citations

Cooperation of Pre-mRNA Sequence Elements in Splice Site Selection

1992 • 90 citations

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

1992 • 90 citations

Resting chondrocytes in culture survive without growth factors, but are sensitive to toxic oxygen metabolites.

1990 • 89 citations

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

1990 • 69 citations

Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein.

1993 • 68 citations

Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP

1992 • 64 citations

RNA annealing activity is intrinsically associated with U2AF

1993 • 59 citations

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.

1992 • 56 citations

Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster.

1991 • 54 citations

Adenosine phosphorothioates (ATP alpha S and ATP tau S) differentially affect the two steps of mammalian pre-mRNA splicing.

1992 • 53 citations

Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly

1992 • 49 citations

Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes.

1992 • 47 citations

A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome.

1992 • 44 citations

Combinatorial splicing of exon pairs by two-site binding of U1 small nuclear ribonucleoprotein particle.

1991 • 42 citations

A novel protein factor is required for use of distal alternative 5' splice sites in vitro.

1991 • 42 citations

An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract.

1992 • 41 citations

Cooperation of pre-mRNA sequence elements in splice site selection.

1992 • 40 citations

The 5' splice site consensus RNA oligonucleotide induces assembly of U2/U4/U5/U6 small nuclear ribonucleoprotein complexes.

1992 • 31 citations

RNA binding proteins, splice site selection, and alternative pre-mRNA splicing.

1992 • 30 citations

RNA processing

1992 • 25 citations

Multiple activities of the human splicing factor ASF.

1992 • 23 citations

Suboptimal 5′ and 3′ splice sites regulate alternative splicing of Drosophila melanogaster myosin heavy chain transcripts in vitro

1992 • 20 citations

Phosphorothioate substitution identifies phosphate groups important for pre-mRNA splicing

1992 • 17 citations

U1—U2 snRNPs interaction induced by an RNA complementary to the 5′ end sequence of U1 snRNA

1992 • 14 citations