Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

Free radicals in biology and medicine

1991 • 17,840 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

2003 • 1,787 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

Lipid hydroperoxide generation, turnover, and effector action in biological systems

1998 • 1,188 citations

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

2003 • 1,119 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

2004 • 1,019 citations

STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES

2004 • 993 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Interaction of reactive oxygen species with ion transport mechanisms

1998 • 659 citations

Overview of Nomenclature of Nuclear Receptors

2006 • 639 citations

Protein-bound acrolein: Potential markers for oxidative stress

1998 • 622 citations

Nutrition and health aspects of free radicals and antioxidants

1994 • 595 citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

2003 • 587 citations

Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

1976 • 552 citations

PPARs and molecular mechanisms of transrepression

2007 • 531 citations

The Molecular Effects of Acrolein

2000 • 514 citations

Oxidative stress: damage to intact cells and organs

1985 • 503 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Reactive oxygen species, mitochondria, apoptosis and aging

1997 • 470 citations

Modulation of PPAR activity via phosphorylation

2007 • 427 citations

Free radicals in biology and medicine

1985 • 416 citations

Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

2001 • 413 citations

Protein‐Bound Acrolein

1999 • 394 citations

Untitled

1997 • 368 citations

Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability Is a Function of Cell Lipid bis-Allylic Hydrogen Content

1994 • 350 citations

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

1998 • 350 citations

Nuclear Receptor Structure: Implications for Function

2006 • 346 citations

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

1999 • 344 citations

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

1998 • 344 citations

Essentiality of fatty acids

1999 • 310 citations

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

2003 • 296 citations

Current Status of Acrolein as a Lipid Peroxidation Product

1999 • 288 citations

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases

2004 • 267 citations

Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein

1997 • 264 citations

LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS

2004 • 262 citations

Liposomes as membrane model for study of lipid peroxidation

1988 • 260 citations

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

2003 • 259 citations

Oxygen Radicals and Tissue Injury

1997 • 257 citations

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

1996 • 251 citations

4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

1999 • 249 citations

Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal

1995 • 231 citations

Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal

1998 • 226 citations

Decomposition of linoleic acid hydroperoxides. Enzymic reactions compared with nonenzymic

1975 • 224 citations

Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome

2004 • 215 citations

An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay

2006 • 210 citations

Hormonal modulation of Δ6 and Δ5 desaturases: case of diabetes

2003 • 206 citations

Very long chain fatty acids in higher animals—A review

1995 • 190 citations

Phospholipase A2s and lipid peroxidation

2000 • 188 citations

Roles of Reactive Oxygen Species: Signaling and Regulation of Cellular Functions

1999 • 188 citations

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

2003 • 180 citations

Formation of N ε-(Hexanonyl)lysine in Protein Exposed to Lipid Hydroperoxide

1999 • 163 citations

Mass spectrometry analysis of oxidized phospholipids

2008 • 146 citations

Effect of ferrous ion and ascorbate-induced lipid peroxidation on liposomal membranes

1981 • 146 citations

Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient rats

1980 • 143 citations

4-Hydroxynonenal Induces Apoptosis via Caspase-3 Activation and CytochromecRelease

2001 • 143 citations

Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences

2000 • 135 citations

Steroidogenic Acute Regulatory Protein Binds Cholesterol and Modulates Mitochondrial Membrane Sterol Domain Dynamics

2001 • 132 citations

High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal

2002 • 127 citations

Mitochondria and free radicals in neurodegenerative diseases

1997 • 124 citations

4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

1990 • 121 citations

Chemical Characterization of a Protein-4-hydroxy-2-nonenal Cross-Link: Immunochemical Detection in Mitochondria Exposed to Oxidative Stress

1996 • 120 citations

Catalytic site‐specific inhibition of the 20S proteasome by 4‐hydroxynonenal

2004 • 118 citations

Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.

1992 • 115 citations

Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine

1998 • 115 citations

Pyridoxamine Traps Intermediates in Lipid Peroxidation Reactions in Vivo

2003 • 113 citations

Diet, Nutrition, and Cancer

1983 • 113 citations

Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4

2001 • 110 citations

Regulation of 4‐Hydroxynonenal Mediated Signaling By Glutathione S‐Transferases

2005 • 103 citations

Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status

2004 • 102 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Identification of Bovine Heart Cytochrome c Oxidase Subunits Modified by the Lipid Peroxidation Product 4-Hydroxy-2-nonenal^,

2002 • 88 citations

Ultraviolet- and Sunlight-Induced Lipid Peroxidation in Liposomal Membrane

1980 • 86 citations

X-ray diffraction evidence for myelin disorder in brain from humans with alzheimer's disease

1984 • 85 citations

Formation of Highly Reactive Cyclopentenone Isoprostane Compounds (A3/J3-Isoprostanes) in Vivo from Eicosapentaenoic Acid

2008 • 83 citations

4-Hydroxynonenal and PPARγ ligands affect proliferation, differentiation, and apoptosis in colon cancer cells

2007 • 81 citations

Effects of the generation of superoxide anion on permeability of liposomes

1977 • 77 citations

The Ability of Melatonin to Counteract Lipid Peroxidation in Biological Membranes

2007 • 74 citations

Evidence for in situ ethanolamine phospholipid adducts with hydroxy-alkenals

2007 • 72 citations

Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation

2002 • 69 citations

Lipid Peroxidation in Sarcoplasmic Reticulum Membranes: Effect on Functional and Biophysical Properties

1993 • 61 citations

Age-related changes in arachidonic acid peroxidation and glutathione-peroxidase activity in human platelets

1992 • 61 citations

Apoptosis signalling by 4-hydroxynonenal: a role for JNK–c-Jun/AP-1 pathway

2007 • 59 citations

Glutathione metabolic enzyme activities in diabetic platelets as a function of glycemic control

1992 • 59 citations

Influence of phospholipid peroxidation on the phase behavior of phosphatidylcholine and phosphatidylethanolamine in aqueous dispersions

1984 • 55 citations

Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells

1996 • 55 citations

Relation of lipid peroxidation to loss of cations trapped in liposomes

1971 • 53 citations

The dual effect of oxidation on lipid bilayer structure

1992 • 51 citations

Identification of Oxidatively Truncated Ethanolamine Phospholipids in Retina and Their Generation from Polyunsaturated Phosphatidylethanolamines

2006 • 47 citations

In vitro production of long chain pyrrole fatty esters from carbonyl-amine reactions.

1995 • 45 citations

The presence of oxidized phosphatidylserine on Fas-mediated apoptotic cell surface

2005 • 42 citations

Reconstitution Studies on the Involvement of Radiation-induced Lipid Peroxidation in Damage to Membrane Enzymes

1983 • 40 citations

Curvature stress and polymorphism in membranes

1996 • 39 citations

Low Levels of Irradiation Modify Lipid Domains in Model Membranes: A Laser Raman Study

1986 • 37 citations

Identification of Toxic 2,4-Decadienal in Oxidized, Low-Density Lipoprotein by Solid-Phase Microextraction

2000 • 35 citations

Formation of ketodienoic fatty acids by the pure pea lipoxygenase-1.

1991 • 35 citations

Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis

2000 • 30 citations

Fluorescent pigments by covalent binding of lipid peroxidation by‐products to protein and amino acids

1985 • 28 citations

Lipid–protein modifications during ascorbate‐Fe²⁺ peroxidation of photoreceptor membranes: protective effect of melatonin

2006 • 27 citations

4‐Hydroxynonenal and cell cycle

2005 • 25 citations

Melatonin preserves arachidonic and docosapentaenoic acids during ascorbate-Fe2+ peroxidation of rat testis microsomes and mitochondria

2003 • 25 citations

Diet, Nutrition and Cancer

1984 • 23 citations

Modifications of protein by polyunsaturated fatty acid ester peroxidation products

2005 • 23 citations

Modification of NMDA receptor by in vitro lipid peroxidation in fetal guinea pig brain

1993 • 23 citations

Characterization of the Enzymatic and Nonenzymatic Reaction of 13-Oxooctadecadienoic Acid with Glutathione

1997 • 22 citations

Cholesterol, Not Polyunsaturated Fatty Acids, is Target Molecule in Oxidation Induced by Reactive Oxygen Species in Membrane of Human Erythrocytes

2006 • 18 citations

The effect of alpha tocopherol, all-trans retinol and retinyl palmitate on the non enzymatic lipid peroxidation of rod outer segments.

1999 • 17 citations

Formation of adducts between 13-oxooctadecadienoic acid (13-OXO) and protein- derived thiols, in vivo and in vitro

1996 • 14 citations

Non-enzymatic lipid peroxidation of rat liver nuclei and chromatin fractions

1998 • 9 citations