Regulation of 4‐Hydroxynonenal Mediated Signaling By Glutathione S‐Transferases

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

GLUTATHIONE TRANSFERASES

2004 • 3,229 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

2001 • 1,485 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

1978 • 686 citations

The ATP-dependent glutathione S-conjugate export pump

1992 • 656 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

An enzyme from rat liver catalysing conjugations with glutathione

1961 • 563 citations

Glutathione S-Transferases - A Review

1999 • 542 citations

Simple Assay for the Level of Total Lipid Peroxides in Serum or Plasma

2003 • 526 citations

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

1999 • 516 citations

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

1985 • 422 citations

Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.

1994 • 412 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Human Glutathione S-Transferases

1998 • 353 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

1993 • 334 citations

Basic aspects of the biochemical reactivity of 4-hydroxynonenal

2003 • 327 citations

Role of Glutathione S-Transferases in Protection against Lipid Peroxidation

2001 • 305 citations

HNE interacts directly with JNK isoforms in human hepatic stellate cells.

1998 • 301 citations

Two Distinct Pathways of Formation of 4-Hydroxynonenal

2001 • 298 citations

4‐Hydroxynonenal in the Pathomechanisms of Oxidative Stress

2000 • 296 citations

The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

2002 • 272 citations

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases

2004 • 267 citations

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

2003 • 259 citations

Microsomal Glutathione Transferase

1983 • 256 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

Simple Procedure for Specific Assay of Lipid Hydroperoxides in Serum or Plasma

2003 • 244 citations

The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase

1995 • 242 citations

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class

2003 • 217 citations

Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver

1980 • 215 citations

Detoxification of electrophilic compounds by glutathione S‐transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs?

2003 • 207 citations

Intracellular metabolism of 4-hydroxynonenal

2003 • 206 citations

Propagation and immortalization of human lens epithelial cells in culture.

1994 • 196 citations

Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress

2001 • 185 citations

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

2003 • 180 citations

The Lipid Peroxidation Product 4‐Hydroxy‐2,3‐Nonenal Increases AP‐1‐Binding Activity Through Caspase Activation in Neurons

2000 • 176 citations

Lipid Peroxidation Product, 4-Hydroxynonenal and Its Conjugate with GSH Are Excellent Substrates of Bovine Lens Aldose Reductase

1995 • 157 citations

Novel Function of Human RLIP76: ATP-Dependent Transport of Glutathione Conjugates and Doxorubicin

2000 • 157 citations

Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources.

2000 • 155 citations

Hydrogen Peroxide. Ubiquitous in Cell Culture and In vivo?

2000 • 154 citations

Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse

2003 • 151 citations

Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

1998 • 149 citations

Curcumin protects against 4-hydroxy-2-trans-nonenal–induced cataract formation in rat lenses

1996 • 148 citations

Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells

1997 • 144 citations

Mercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in the Rat

1995 • 139 citations

Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways

2003 • 138 citations

Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate

1993 • 133 citations

4-Hydroxynonenal from pathology to physiology

2003 • 131 citations

The Role of Human Glutathione S-Transferases hGSTA1-1 and hGSTA2-2 in Protection against Oxidative Stress

1999 • 126 citations

Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

1994 • 125 citations

Effects of mGST A4 Transfection on 4-Hydroxynonenal-Mediated Apoptosis and Differentiation of K562 Human Erythroleukemia Cells

1999 • 124 citations

Antioxidative Function and Substrate Specificity of NAD(P)H- dependent Alkenal/one Oxidoreductase

2001 • 123 citations

Transfection of mGSTA4 in HL-60 Cells Protects against 4-Hydroxynonenal-Induced Apoptosis by Inhibiting JNK-Mediated Signaling

2001 • 122 citations

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7).

1994 • 118 citations

Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the α-class isozymes against lipid peroxidation

1992 • 117 citations

4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

2002 • 115 citations

4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine

1995 • 114 citations

Covalent modifications of aminophospholipids by 4-hydroxynonenal

1998 • 110 citations

Several Closely Related Glutathione S-Transferase Isozymes Catalyzing Conjugation of 4-Hydroxynonenal Are Differentially Expressed in Human Tissues

1994 • 105 citations

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

1999 • 99 citations

Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenal

1993 • 96 citations

Aldose Reductase Mediates Mitogenic Signaling in Vascular Smooth Muscle Cells

2002 • 96 citations

4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions

2003 • 93 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

Increased Levels of 4-Hydroxynonenal Modified Proteins in Plasma of Children with Autoimmune Diseases

1997 • 92 citations

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

2003 • 91 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF‐α in human lens epithelial cells

2002 • 90 citations

Dinitrophenyl glutathione efflux from human erythrocytes is primary active ATP-dependent transport

1986 • 88 citations

Cloning and heterologous expression of cDNA encoding class Alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds

1992 • 86 citations

Role of α Class Glutathione S-Transferases as Antioxidant Enzymes in Rodent Tissues

2002 • 84 citations

RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics

2002 • 83 citations

Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis

2004 • 77 citations

Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells

2001 • 76 citations

Role of Ultraviolet A-Induced Oxidative DNA Damage in Apoptosis via Loss of Mitochondrial Membrane Potential and Caspase-3 Activation

1998 • 75 citations

4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase

1996 • 74 citations

Increased Resistance to Oxidative Stress in Transfected Cultured Cells Overexpressing GlutathioneS-Transferase mGSTA4-4

1997 • 69 citations

4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway

2004 • 68 citations

Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity

2003 • 68 citations

Functional Reassembly of ATP-Dependent Xenobiotic Transport by the N- and C-Terminal Domains of RLIP76 and Identification of ATP Binding Sequences

2001 • 67 citations

Membrane Association of Glutathione S-Transferase mGSTA4-4, an Enzyme That Metabolizes Lipid Peroxidation Products

2002 • 65 citations

Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues

2001 • 65 citations

RLIP76 Is the Major ATP-Dependent Transporter of Glutathione-Conjugates and Doxorubicin in Human Erythrocytes

2001 • 63 citations

Transfection with 4‐hydroxynonenal‐metabolizing glutathione S‐transferase isozymes leads to phenotypic transformation and immortalization of adherent cells

2004 • 60 citations

Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2.

2002 • 59 citations

A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues

1994 • 59 citations

Autoxidative Transformation of Chiral ω6 Hydroxy Linoleic and Arachidonic Acids to Chiral 4-Hydroxy-2E-nonenal

2004 • 58 citations

A subgroup of class α glutathione S‐transferases Cloning of cDNA for mouse lung glutathione S‐transferase GST 5.7

1992 • 56 citations

4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.

1999 • 56 citations

Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76

2003 • 56 citations

4-Hydroxynonenal Modifies the Effects of Serum Growth Factors on the Expression of the c-fos Proto-Oncogene and the Proliferation of HeLa Carcinoma Cells

1998 • 55 citations

Effects of 4-Hydroxynonenal, A Product of Lipid Peroxidation, on Cell Proliferation and Ornithine Decarboxylase Activity

1991 • 55 citations

A novel dinitrophenylglutathione‐stimulated ATPase is present in human erythrocyte membranes

1988 • 53 citations

Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity

2003 • 53 citations

4-Hydroxynonenal and transforming growth factor-β1 expression in colon cancer

2003 • 50 citations

Effect of Oxidative Stress by Iron on 4-Hydroxynonenal Formation and Proliferative Activity In Hepatomas of Different Degrees of Differentiation

1997 • 48 citations

ATP-Dependent Human Erythrocyte Glutathione-Conjugate Transporter. II. Functional Reconstitution of Transport Activity

1998 • 46 citations

Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells

2003 • 46 citations

Inhibition of doxorubicin-induced apoptosis in vivo by 2-deoxy-D-glucose.

1993 • 44 citations

In vivo involvement of cytochrome P450 4A family in the oxidative metabolism of the lipid peroxidation product trans-4-hydroxy-2-nonenal, using PPARα-deficient mice

1999 • 42 citations

The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins.

2001 • 42 citations

4-Hydroxynonenal Specifically Inhibits c-myb but Does Not Affect c-fos Expressions in HL-60 Cells

1996 • 41 citations

4-Hydroxynonenal Prevents NO Production in Vascular Smooth Muscle Cells by Inhibiting Nuclear Factor-κB–Dependent Transcriptional Activation of Inducible NO Synthase

2001 • 35 citations

4-Hydroxynonenal-Induced MEL Cell Differentiation Involves PKC Activity Translocation

2000 • 34 citations

Identification of a Novel Human GlutathioneS-Transferase Using Bioinformatics

1998 • 34 citations

Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver

2000 • 33 citations

4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells

2002 • 32 citations

Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro

1994 • 32 citations

Role of PKC-dependent pathways in HNE-induced cell protein transport and secretion

2003 • 29 citations

4-Hydroxy-2-nonenal as a COX-2 inducer

2003 • 29 citations

Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal.

2002 • 27 citations

Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells

1996 • 26 citations

Inhibition of Melanoma B16-F10 Growth by Lipid Peroxidation Product 4-Hydroxynonenal

1995 • 23 citations

Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes.

2001 • 15 citations

Nutrition and Cancer Prevention

2009 • 12 citations