Modulation of PPAR activity via phosphorylation

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

2001 • 1,408 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

GSK3 takes centre stage more than 20 years after its discovery

2001 • 1,298 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors

2000 • 563 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site

1997 • 544 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

2006 • 507 citations

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

2000 • 481 citations

Deactivation of peroxisome proliferator–activated receptor-α during cardiac hypertrophic growth

2000 • 452 citations

Regulation of Peroxisome Proliferator-activated Receptor γ Activity by Mitogen-activated Protein Kinase

1997 • 446 citations

Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I

2001 • 421 citations

AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1

2005 • 396 citations

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

1996 • 378 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements

1997 • 367 citations

Interdomain communication regulating ligand binding by PPAR-γ

1998 • 344 citations

Cross-Talk between Peptide Growth Factor and Estrogen Receptor Signaling Pathways

1998 • 334 citations

Nuclear receptors: integration of multiple signalling pathways through phosphorylation

2003 • 286 citations

Insulin- and Mitogen-activated Protein Kinase-mediated Phosphorylation and Activation of Peroxisome Proliferator-activated Receptor γ

1996 • 272 citations

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues

2006 • 269 citations

A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis

2000 • 265 citations

p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α

2001 • 253 citations

c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-γ1 and Negatively Regulates Its Transcriptional Activity

1999 • 228 citations

Activation of Peroxisome Proliferator-Activated Receptors (PPARs) by Their Ligands and Protein Kinase A Activators

2000 • 207 citations

Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

2003 • 205 citations

Interferon-γ-mediated Activation and Ubiquitin-Proteasome-dependent Degradation of PPARγ in Adipocytes

2002 • 185 citations

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.

1996 • 179 citations

Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain

1999 • 174 citations

Peroxisome Proliferator-activated Receptor δ (PPARδ)-mediated Regulation of Preadipocyte Proliferation and Gene Expression Is Dependent on cAMP Signaling

2001 • 172 citations

Transforming Growth Factor-β1 (TGF-β1) and TGF-β2 Decrease Expression of CD36, the Type B Scavenger Receptor, through Mitogen-activated Protein Kinase Phosphorylation of Peroxisome Proliferator-activated Receptor-γ

2000 • 168 citations

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins

2003 • 161 citations

Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor

1997 • 153 citations

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)

1998 • 141 citations

A Truncated Human Peroxisome Proliferator-Activated Receptor α Splice Variant with Dominant Negative Activity

1999 • 140 citations

Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-α (PPARα) Signaling Pathways

1999 • 133 citations

Direct Activation of Glucose Transport in Primary Human Myotubes After Activation of Peroxisome Proliferator–Activated Receptor δ

2005 • 130 citations

Peroxisome Proliferator–Activated Receptors: A Critical Link among Fatty Acids, Gene Expression and Carcinogenesis

1999 • 129 citations

Evidence That Peroxisome Proliferator-activated Receptor α Is Complexed with the 90-kDa Heat Shock Protein and the Hepatitis Virus B X-associated Protein 2

2003 • 110 citations

Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis

1999 • 104 citations

Ligand-induced Peroxisome Proliferator-activated Receptor α Conformational Change

1997 • 103 citations

Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor δ-mediated transactivation

2002 • 98 citations

The Protein Kinase C Signaling Pathway Regulates a Molecular Switch between Transactivation and Transrepression Activity of the Peroxisome Proliferator-Activated Receptor α

2004 • 94 citations

Peroxisome Proliferators Activate Extracellular Signal-regulated Kinases in Immortalized Mouse Liver Cells

1997 • 83 citations

Adipose‐specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARγ agonist's effects on edema and weight gain

2006 • 82 citations

Heat Shock Protein-90 (Hsp90) Acts as a Repressor of Peroxisome Proliferator-Activated Receptor-α (PPARα) and PPARβ Activity

2003 • 80 citations

Rapid induction of peroxisome proliferator–activated receptor γ expression in human monocytes by monosodium urate monohydrate crystals

2003 • 73 citations

Activation of Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) Increases the Expression of Prostaglandin E2 Receptor Subtype EP4

2005 • 58 citations

Growth regulation by peroxisome proliferators: opposing activities in early and late G1.

1996 • 56 citations

Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643

2003 • 51 citations

Selective Intranuclear Redistribution of PPAR Isoforms by RXRα

2002 • 49 citations

Both Coactivator LXXLL Motif-dependent and -independent Interactions Are Required for Peroxisome Proliferator-activated Receptor γ (PPARγ) Function

2000 • 48 citations

Regulation of Peroxisome Proliferator-Activated Receptor α by Protein Kinase C

2005 • 39 citations

Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate

1999 • 38 citations

Conserved amino acids in the ligand-binding and τi domains of the peroxisome proliferator-activated receptor α are necessary for heterodimerization with RXR

1999 • 31 citations

Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor α are altered by the centrosome-associated protein CAP350

2004 • 30 citations

Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>(PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>)

2006 • 22 citations