Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Oxyradicals and DNA damage

2000 • 1,876 citations

Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate

1999 • 1,279 citations

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.

1996 • 1,269 citations

Oxidative Decay of DNA

1997 • 938 citations

Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid

1996 • 861 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α

1967 • 403 citations

Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

1994 • 368 citations

Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts

1996 • 345 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

1998 • 267 citations

Characterization of 4-Oxo-2-nonenal as a Novel Product of Lipid Peroxidation

2000 • 236 citations

Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids

1990 • 225 citations

Cancer Chemoprevention: Progress and Promise

1998 • 196 citations

The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

2001 • 184 citations

Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells during Apoptosis and Cell Differentiation

1998 • 145 citations

Covalent Modifications to 2‘-Deoxyguanosine by 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation

1999 • 134 citations

Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells.

2000 • 129 citations

Characterization of 2‘-Deoxyadenosine Adducts Derived from 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation

2000 • 99 citations

The Role of COX‐2 in Intestinal Cancer

1999 • 99 citations

4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression

2000 • 95 citations

Potential Problems of Ascorbate and Iron Supplementation: Pro-Oxidant Effect in Vivo?

2000 • 80 citations

Enhancement of hydroperoxide-dependent lipid peroxidation in rat liver microsomes by ascorbic acid

1990 • 71 citations

Quantification of Etheno-DNA Adducts Using Liquid Chromatography, On-Line Sample Processing, and Electrospray Tandem Mass Spectrometry

2000 • 70 citations

Dna Damage by Iron and Hydrogen Peroxide in Vitro and in Vivo

1998 • 61 citations

Stereochemistry of Oxygenation of Linoleic Acid Catalyzed by Prostaglandin–Endoperoxide H Synthase-2

1998 • 49 citations

Soybean Lipoxygenase-1 Oxidizes 3Z-Nonenal

1998 • 43 citations

Synthesis of trans‐4,5‐epoxy‐(E)‐2‐decenal and its deuterated analog used for the development of a sensitive and selective quantification method based on isotope dilution assay with negative chemical ionization

1999 • 37 citations