Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Roles of PPARs in health and disease

2000 • 1,941 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

1996 • 715 citations

Oxidative stress and cell cycle checkpoint function11Both Drs. Paules and Kaufmann received their doctoral degrees in Experimental Pathology from the University of North Carolina at Chapel Hill School of Medicine (in 1984 and 1979, respectively).

2000 • 516 citations

The role of PPAR-γ in macrophage differentiation and cholesterol uptake

2001 • 507 citations

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells

2000 • 439 citations

Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

2000 • 402 citations

Peroxisome Proliferator-Activated Receptors

2003 • 373 citations

4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

1999 • 249 citations

A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.

1999 • 234 citations

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis

2000 • 224 citations

1α,25-Dihyroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes

1983 • 206 citations

Peroxisome proliferator-activated receptor agonists

1997 • 197 citations

Keratinocyte Differentiation is Stimulated by Activators of the Nuclear Hormone Receptor PPARα

1998 • 175 citations

Chemotactic Activity of the Lipid Peroxidation Product 4-Hydroxynonenal and Homologous Hydroxyalkenals

1986 • 120 citations

Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.

1997 • 97 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Peroxisome proliferator‐activated receptors in tumorigenesis: Targets of tumour promotion and treatment

2000 • 76 citations

Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.

1999 • 72 citations

Thiazolidinedione Induces Apoptosis and Monocytic Differentiation in the Promyelocytic Leukemia Cell Line HL60

1999 • 63 citations

4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.

1999 • 56 citations

Advanced Glycation End Product-Induced Peroxisome Proliferator-Activated Receptor γ Gene Expression in the Cultured Mesangial Cells

1999 • 56 citations

Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells

1996 • 55 citations

4-Hydroxynonenal-Induced MEL Cell Differentiation Involves PKC Activity Translocation

2000 • 34 citations

Bezafibrate as differentiating factor of human myeloid leukemia cells

1999 • 32 citations

Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-β-D-Arabinofuranosylcytosine

2000 • 23 citations

Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal

2001 • 20 citations

Effect of phorbol esters on iron uptake in human hematopoietic cell lines.

1984 • 17 citations

Potentiating effects of clofibric acid on the differentiation of HL-60 human promyelocytic leukemia cells induced by retinoids.

1995 • 14 citations

Retinoids Induce U937 Cells to Express Macrophage Phenotype

1986 • 13 citations

Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate

1998 • 9 citations