Interpreting cDNA sequences: Some insights from studies on translation

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

The scanning model for translation: an update.

1989 • 3,525 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Signal sequences

1985 • 2,179 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

1987 • 1,189 citations

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Trna: Structure, Biosynthesis, and Function

1995 • 896 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

1986 • 684 citations

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

1989 • 618 citations

Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes.

1990 • 550 citations

Effects of Intercistronic Length on the Efficiency of Reinitiation by Eucaryotic Ribosomes

1987 • 540 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Context Effects and Inefficient Initiation at Non-AUG Codons in Eucaryotic Cell-Free Translation Systems

1989 • 471 citations

Regulation of Translation in Eukaryotic Systems

1992 • 467 citations

Molecular cloning of the rat stomach (H+ + K+)-ATPase.

1986 • 463 citations

Characterization of cDNA for precursor of human luteinizing hormone releasing hormone

1984 • 444 citations

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

1995 • 421 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

Bifunctional messenger RNAs in eukaryotes

1986 • 405 citations

Mutation in the Gene Encoding the Stimulatory G Protein of Adenylate Cyclase in Albright's Hereditary Osteodystrophy

1990 • 402 citations

Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain

1990 • 395 citations

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

1993 • 372 citations

Identification and characterization of the gene causing type 1 spinocerebellar ataxia

1994 • 369 citations

The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons

1995 • 347 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing

1995 • 321 citations

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

1993 • 313 citations

Site-directed mutagenesis

1986 • 286 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Cell cycle regulation of human WEE1.

1995 • 281 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

Structure and cell cycle-regulated transcription of the human cyclin A gene.

1994 • 272 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.

1994 • 270 citations

Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

1991 • 265 citations

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

1996 • 261 citations

Adherence to the first-AUG rule when a second AUG codon follows closely upon the first.

1995 • 254 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.

1991 • 243 citations

Circumstances and Mechanisms of Inhibition of Translation by Secondary Structure in Eucaryotic mRNAs

1989 • 238 citations

Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.

1990 • 237 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed.

1988 • 229 citations

Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase.

1986 • 228 citations

Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.

1988 • 220 citations

Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development.

1992 • 219 citations

The primary structure of rat ribosomal protein S6.

1988 • 210 citations

Organization of the Murine Mx Gene and Characterization of Its Interferon- and Virus-Inducible Promoter

1988 • 206 citations

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

1990 • 205 citations

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

1989 • 204 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

1994 • 202 citations

The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo

1992 • 200 citations

Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

1994 • 200 citations

cDNA that encodes active agrin

1992 • 199 citations

Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.

1985 • 199 citations

tRNA _i ^met Functions in Directing the Scanning Ribosome to the Start Site of Translation

1988 • 199 citations

The Chicken Progesterone Receptor A and B Isoforms Are Products of an Alternate Translation Initiation Event

1989 • 196 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

1993 • 190 citations

The Mouse Proteinase-activated Receptor-2 cDNA and Gene

1995 • 187 citations

Ionomycin, Thapsigargin, Ryanodine, and Sperm Induced Ca2+ Release Increase during Meiotic Maturation of Mouse Oocytes

1995 • 184 citations

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

1995 • 178 citations

Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution.

1994 • 177 citations

Post-transcriptional regulation of the human transforming growth factor-beta 1 gene.

1992 • 175 citations

Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.

1985 • 172 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

Structural organization of multiple rat calmodulin genes

1989 • 162 citations

Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A

1985 • 157 citations

Molecular Cloning of Human Fibroblast Hyaluronic Acid-binding Protein Confirms Its Identity with P-32, a Protein Co-purified with Splicing Factor SF2

1996 • 153 citations

Initiation of translation of the cauliflower mosaic virus genome from a polycistronic mRNA: evidence from deletion mutagenesis

1984 • 152 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1

1991 • 147 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7.

1992 • 144 citations

Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family

1985 • 138 citations

A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes

1992 • 137 citations

Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.

1989 • 135 citations

RSK3 Encodes a Novel pp90^rsk Isoform with a Unique N-Terminal Sequence: Growth Factor-Stimulated Kinase Function and Nuclear Translocation

1995 • 135 citations

cDNA Cloning, Gene Organization, and Chromosomal Localization of a Human Mercurial Insensitive Water Channel

1995 • 133 citations

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

1988 • 133 citations

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix.

1995 • 132 citations

Initiation codon mutation as a cause of alpha thalassemia.

1984 • 130 citations

Translation initiation at alternate in-frame AUG codons in the rabies virus phosphoprotein mRNA is mediated by a ribosomal leaky scanning mechanism

1995 • 129 citations

Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene.

1989 • 128 citations

The Aspergillus nidulans brlA regulatory locus consists of overlapping transcription units that are individually required for conidiophore development.

1993 • 127 citations

Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro.

1991 • 126 citations

The mouse osteopontin gene. Expression in monocytic lineages and complete nucleotide sequence.

1990 • 125 citations

Hsp47 and Cyclophilin B Traverse the Endoplasmic Reticulum with Procollagen into Pre-Golgi Intermediate Vesicles

1995 • 122 citations

cRACE: a simple method for identification of the 5′ end of mRNAs

1995 • 122 citations

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

1992 • 121 citations

Gene expression of mouse choline acetyltransferase. Alternative splicing and identification of a highly active promoter region.

1992 • 120 citations

Competition between nuclear localization and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF3.

1994 • 119 citations

Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells.

1987 • 118 citations

Cell-specific translational regulation of S-adenosylmethionine decarboxylase mRNA. Dependence on translation and coding capacity of the cis-acting upstream open reading frame.

1993 • 117 citations

Molecular Cloning of NIPP-1, a Nuclear Inhibitor of Protein Phosphatase-1, Reveals Homology with Polypeptides Involved in RNA Processing

1995 • 115 citations

Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis.

1994 • 114 citations

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

1991 • 113 citations

A cyclophilin-related protein involved in the function of natural killer cells.

1993 • 112 citations

The Human Decorin Gene: Intron-Exon Organization, Discovery of Two Alternatively Spliced Exons in the 5′ Untranslated Region, and Mapping of the Gene to Chromosome 12q23

1993 • 111 citations

Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).

1989 • 111 citations

Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)

1989 • 110 citations

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

1989 • 110 citations

Translational discrimination of mRNAs coding for human insulin-like growth factor II.

1990 • 108 citations

Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells.

1990 • 108 citations

Distinct transcription start sites generate two forms of BRCA1 mRNA

1995 • 107 citations

Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains.

1994 • 105 citations

Transcriptional Regulation of Estrogen Receptor in Breast Carcinomas

1995 • 104 citations

Control of start codon choice on a plant viral RNA encoding overlapping genes.

1993 • 104 citations

Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.

1989 • 102 citations

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14

1988 • 101 citations

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

1995 • 99 citations

Structure of human milk bile salt activated lipase

1991 • 99 citations

Identification of a major up-stream transcription start site for the human progonadotropin-releasing hormone gene used in reproductive tissues and cell lines.

1993 • 96 citations

A Large Variety of Alternatively Spliced and Differentially Expressed mRNAs Are Encoded by the Human Acute Myeloid Leukemia Gene AML1

1996 • 96 citations

Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.

1990 • 95 citations

A highly sensitive method for mapping the 5′ termini of mRNAs

1993 • 94 citations

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

1994 • 94 citations

Translational repression of brlA expression prevents premature development in Aspergillus.

1993 • 93 citations

Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.

1986 • 93 citations

Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors

1995 • 92 citations

Structure of the promoter for chicken alpha 2 type I collagen gene.

1981 • 92 citations

Features in the 5′ non-coding sequences of rabbit α and β-globin mRNAs that affect translational efficiency

1994 • 91 citations

The SMC family: Novel motor proteins for chromosome condensation?

1994 • 91 citations

Characterization of the gene encoding human platelet glycoprotein IX.

1993 • 91 citations

Translation initiation at an ACG triplet in mammalian cells.

1987 • 90 citations

Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+ release-mediating protein from endoplasmic reticulum.

1996 • 89 citations

The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.

1990 • 88 citations

Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex

1990 • 88 citations

Biochemical Characterization of Human PC‐1, an Enzyme Possessing Alkaline Phosphodiesterase I and Nucleotide Pyrophosphatase Activities

1994 • 86 citations

The 5' untranslated region of mRNA for ribosomal protein S19 is involved in its translational regulation during Xenopus development.

1990 • 86 citations

Tissue specific expression of the retinoic acid receptor-beta 2: regulation by short open reading frames in the 5'-noncoding region.

1994 • 85 citations

Subcellular Localization of Human Voltage-dependent Anion Channel Isoforms

1995 • 84 citations

Regulation of Expression of the Alternative mRNAs of the Rat α-Thyroid Hormone Receptor Gene

1989 • 83 citations

Effect of the cap structure on pre-mRNA splicing in Xenopus oocyte nuclei.

1989 • 83 citations

Splicing of cauliflower mosaic virus 35S RNA is essential for viral infectivity.

1995 • 83 citations

Heparin-like Molecules on the Cell Surface Potentiate Binding of Diphtheria Toxin to the Diphtheria Toxin Receptor/Membrane-anchored Heparin-binding Epidermal Growth Factor-like Growth Factor

1995 • 83 citations

Structure, Sequence, Expression, and Chromosomal Localization of the Human V1aVasopressin Receptor Gene

1996 • 80 citations

Regulation and Expression of a Growth Arrest-Specific Gene (gas5) during Growth, Differentiation, and Development

1992 • 80 citations

The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters.

1994 • 79 citations

An Efficient Strategy To Isolate Full-Length cDNAs Based on an mRNA Cap Retention Procedure (CAPture)

1995 • 79 citations

Characterization of human cDNA and genomic clones for glial fibrillary acidic protein

1990 • 76 citations

Structure of the human perforin gene. A simple gene organization with interesting potential regulatory sequences.

1989 • 75 citations

The Alkali Light Chains of Human Smooth and Nonmuscle Myosins Are Encoded by a Single Gene

1989 • 73 citations

Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs

1994 • 73 citations

Heterogeneity at the 5′ end of rat acetyl-coenzyme A carboxylase mRNA

1989 • 71 citations

Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources

1990 • 71 citations

The Human Tryptophan Hydroxylase Gene

1995 • 69 citations

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.

1995 • 68 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.

1993 • 67 citations

Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells.

1994 • 66 citations

Studies on the mechanism of translational enhancement by the 5′‐leader sequence of tobacco mosaic virus RNA

1988 • 65 citations

The complete nucleotide sequence of the human gonadotropin-releasing hormone gene

1989 • 64 citations

brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain.

1994 • 64 citations

Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts.

1993 • 63 citations

Identification of a Human Gene (HCK) that Encodes a Protein-Tyrosine Kinase and is Expressed in Hemopoietic Cells

1987 • 63 citations

Thyroid hormone receptor transcriptional activity is potentially autoregulated by truncated forms of the receptor.

1992 • 63 citations

Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene.

1990 • 62 citations

Human platelet glycoprotein IX

1990 • 61 citations

Genomic organization, sequence analysis, and chromosomal localization of the human car☐yl ester lipase (CEL) gene and a CEL-like (CELL) gene

1992 • 61 citations

Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-m RNA splicing factor SF2

1993 • 60 citations

Translational inhibition by a human cytomegalovirus upstream open reading frame despite inefficient utilization of its AUG codon

1995 • 60 citations

Alternate Translation Initiation Codons Can Create Functional Forms of Cystic Fibrosis Transmembrane Conductance Regulator

1995 • 60 citations

Protein structure and gene organization of mouse lactate dehydrogenase‐A isozyme

1985 • 60 citations

Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein.

1994 • 59 citations

A Neuronal Protein Tyrosine Phosphatase Induced by Nerve Growth Factor

1995 • 58 citations

Purification of human milk bile salt-activated lipase

1983 • 58 citations

Structure of bovine adrenal dopamine .beta.-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide

1989 • 58 citations

Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region.

1994 • 57 citations

Translation of equine infectious anemia virus bicistronic tat-rev mRNA requires leaky ribosome scanning of the tat CTG initiation codon

1993 • 55 citations

Rat liver NAD(P)H: Quinone reductase

1989 • 55 citations

The Structure of the Mouse Cathepsin B Gene and Its Putative Promoter

1991 • 55 citations

Identification of a major up-stream transcription start site for the human progonadotropin-releasing hormone gene used in reproductive tissues and cell lines

1993 • 55 citations

Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity

1994 • 54 citations

Multiple Promoters in Rat Acyl-CoA Synthetase Gene Mediate Differential Expression of Multiple Transcripts with 5′-End Heterogeneity

1995 • 53 citations

Mechanism of Translation of Monocistronic and Multicistronic Human Immunodeficiency Virus Type 1 mRNAs

1992 • 52 citations

A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene.

1991 • 51 citations

Primary structure of rat ribosomal protein S2. A ribosomal protein with arginine-glycine tandem repeats and RGGF motifs that are associated with nucleolar localization and binding to ribonucleic acids.

1991 • 51 citations

Cloning and characterization of the gene encoding rabbit cardiac calsequestrin

1991 • 50 citations

Identification of Two Novel Regulatory Elements within the 5′-Untranslated Region of the Human Sγ-Globin Gene

1995 • 50 citations

The CpG island in the 5′ region of the G6PD gene of man and mouse

1991 • 50 citations

Retina-specifically Expressed Novel Subtypes of Bovine Cyclophilin

1995 • 50 citations

Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated Cells

1995 • 50 citations

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.

1990 • 50 citations

Initiator tRNAs and Initiation of Protein Synthesis

2014 • 50 citations

A mammalian arginine/lysine transporter uses multiple promoters.

1995 • 49 citations

Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein.

1987 • 49 citations

A re-examination of the 5' termini of mouse dihydrofolate reductase RNA.

1986 • 48 citations

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.

1994 • 48 citations

An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency.

1992 • 47 citations

ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages.

1994 • 47 citations

The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation

1995 • 47 citations

An Initiation Codon Mutation in the ApoC-II Gene (ApoC-II Paris) of a Patient with a Deficiency of Apolipoprotein C-II

1989 • 46 citations

Novel PKU mutation on haplotype 2 in French-Canadians.

1989 • 46 citations

Posttranscriptional mRNA processing as a mechanism for regulation of human A1 adenosine receptor expression.

1994 • 45 citations

Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus

1994 • 45 citations

Distinct promoters direct neuronal and nonneuronal expression of rat aromatic L-amino acid decarboxylase.

1992 • 44 citations

Cloning and Characterization of the Human Insulin-Like Growth Factor-I Receptor Gene 5′-Flanking Region

1992 • 44 citations

A Highly Conserved Mouse Gene with a Propensity To Form Pseudogenes in Mammals

1988 • 43 citations

An Initiation Codon Mutation as a Cause of a β-Thalassemia

1990 • 42 citations

Chromosomal Protein HMG-14

1989 • 42 citations

Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine.

1993 • 42 citations

Cloning and analysis of calbindin-D28K cDNA and its expression in the central nervous system

1989 • 42 citations

Human Decorin Gene: Intron-Exon Junctions and Chromosomal Localization

1993 • 42 citations

Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).

1993 • 42 citations

Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot.

1994 • 41 citations

Bovine dopamine beta-hydroxylase cDNA. Complete coding sequence and expression in mammalian cells with vaccinia virus vector.

1990 • 40 citations

Structure of the Human Gastric H,K-ATPase Gene and Comparison of the 5′-Flanking Sequences of the Human and Rat Genes

1990 • 39 citations

Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.

1990 • 39 citations

Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2

1993 • 38 citations

Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family.

1986 • 38 citations

Structural organization of the mouse cytosolic malate dehydrogenase gene: Comparison with that of the mouse mitochondrial malate dehydrogenase gene

1988 • 37 citations

Complete nucleotide sequence and characterization of the 5'-flanking region of mammalian elongation factor 2 gene.

1988 • 37 citations

Molecular Characterization of a Novel Transcription Factor That Controls Stromelysin Expression

1995 • 36 citations

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms

1995 • 35 citations

Structure of a gene coding for human HMG2 protein.

1992 • 35 citations

POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue

1995 • 35 citations

Complete primary structure of the transacylase (E2b) subunit of the human branched chain α-keto acid dehydrogenase complex

1989 • 34 citations

Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes.

1990 • 34 citations

Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis.

1994 • 33 citations

Most of the homeobox-containing Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein.

1990 • 31 citations

Corruption of genomic databases with anomalous sequence

1992 • 30 citations

Nucleotide sequence of bovine acidic fibroblast growth factor cDNA

1988 • 29 citations

Nucleotide sequence of the putative regulatory region of mouse lactate dehydrogenase-A gene

1986 • 29 citations

Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene.

1992 • 28 citations

Structural Characterization of SIL, a Gene Frequently Disrupted in T-Cell Acute Lymphoblastic Leukemia

1991 • 28 citations

A testis-specific promoter in the rat vasopressin gene.

1994 • 28 citations

Sequence of the cDNA encoding ovine tumor necrosis factor-α: problems with cloning by inverse PCR

1991 • 28 citations

The ltk gene encodes a novel receptor-type protein tyrosine kinase.

1991 • 28 citations

Transcriptional Regulation of the Rat Insulin-like Growth Factor-I Gene Involves Metabolism-dependent Binding of Nuclear Proteins to a Downstream Region

1995 • 28 citations

Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region.

1992 • 28 citations

Novel mutation at the initiation codon in the Norrie disease gene in two Japanese families

1995 • 27 citations

Dual transcriptional control by Ear3/COUP: negative regulation through the DR1 direct repeat and positive regulation through a sequence downstream of the transcriptional start site of the mouse mammary tumor virus promoter.

1995 • 27 citations

Alterations of the three short open reading frames in the Rous sarcoma virus leader RNA modulate viral replication and gene expression

1993 • 26 citations

The 5′ Untranslated Region of mRNA for Ribosomal Protein S19 Is Involved in Its Translational Regulation during Xenopus Development

1990 • 25 citations

Mutation creates an open reading frame within the 5' untranslated region of macaque erythrocyte carbonic anhydrase (CA) I mRNA that suppresses CA I expression and supports the scanning model for translation.

1992 • 23 citations

Characterization of the Human N-ras Promoter Region

1991 • 21 citations

Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution.

1995 • 19 citations

Transcription of the Rat and Mouse Proenkephalin Genes Is Initiated at Distinct Sites in Spermatogenic and Somatic Cells

1990 • 19 citations

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene.

1994 • 19 citations

Primary structure of ovine tumor necrosis factor alpha cDNA

1990 • 18 citations

Two new mutations in a late infantile Tay-Sachs patient are both in exon 1 of the beta-hexosaminidase alpha subunit gene.

1993 • 18 citations

Comparative analysis of two alternative first exons reported for the mouse osteopontin gene

1993 • 18 citations

Thyroid Hormone Receptor Transcriptional Activity Is Potentially Autoregulated by Truncated Forms of the Receptor

1992 • 18 citations

Identification of the Serum-Responsive Transcription Initiation Site of the Zinc Finger Gene Krox-20

1990 • 17 citations

Biosynthesis of Human Fibroblast Growth Factor-5

1991 • 16 citations

Human Interferon Regulatory Factor 1: Intron-Exon Organization

1992 • 16 citations

Role of TAR RNA splicing in translational regulation of simian immunodeficiency virus from rhesus macaques

1992 • 15 citations

Effects of the open reading frames in the Rous sarcoma virus leader RNA on translation

1993 • 14 citations

Sequence of the rat serine dehydratase gene

1988 • 14 citations

BZP, a Novel Serum-Responsive Zinc Finger Protein That Inhibits Gene Transcription

1994 • 13 citations

Cloning of full coding chicken cDNAs for the homeobox-containing geneHoxd-13

1993 • 12 citations

Identification of a brain-specific protein kinase Cζ pseudogene (ΨPKCζ) transcript

1995 • 12 citations

The Mouse Apolipoprotein C1 Gene: Structure and Expression

1993 • 12 citations

Organization and Structure of the 5′ Flanking Region of the Rat Serine Dehydratase Gene1

1990 • 12 citations

Most of the Homeobox-Containing Xhox 36 Transcripts in Early Xenopus Embryos Cannot Encode a Homeodomain Protein

1990 • 11 citations

Alternative Splicing of Fibroblast Growth Factor 1 (FGF-1) Transcripts: A Cellular Dilemma in Determining Exon Selection and Exclusion

1994 • 11 citations

Correction of the N-Terminal Sequences of the Human Plastin Isoforms by Using Anchored Polymerase Chain Reaction: Identification of a Potential Calcium-Binding Domain

1990 • 10 citations

Enhanced translational efficiency of a novel transforming growth factor β3 mRNA in human breast cancer cells

1994 • 10 citations

Effects of c-myc first exons and 5' synthetic hairpins on RNA translation in oocytes and early embryos of Xenopus laevis.

1996 • 10 citations

A 13 base pair deletion in exon 1 of HPRTIllinois forms a functional GUG initiation codon

1994 • 9 citations

Structure of the Gene Coding for the Human Retinoic Acid-Inducible Factor, MK

1993 • 7 citations

Three different calmodulin-encoding cDNAs isolated by a modified 5'-RACE using degenerate oligodeoxyribonucleotides

1994 • 7 citations

Structural characterization of a brain-specific promoter region directing transcription of the rat prepro-gastrin-releasing peptide gene

1990 • 7 citations

‘Race no more’: an alternative approach to cloning the 5′end of transcripts

1994 • 4 citations

The long leader sequence of the mouse ornithine decarboxylase mRNA, previously suspected to be a cloning artifact, is probably a product of recombination with a MuLV-like retrovirus

1991 • 3 citations