A functional p53-responsive intronic promoter is contained within the humanmdm2gene

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

The tumore suppressor p53

1993 • 336 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

1993 • 250 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

Binding of a simian virus 40 T antigen-related protein to DNA

1981 • 233 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

What the papers say: The p53‐mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?

1993 • 205 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 • 162 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

1995 • 136 citations

The p53 tumor suppressor protein: meeting review.

1993 • 128 citations

p53 oligomerization and DNA looping are linked with transcriptional activation.

1994 • 127 citations

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest.

1992 • 123 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.

1993 • 42 citations