ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

Evolutionary families of peptidases

1993 • 897 citations

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.

1993 • 734 citations

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.

1993 • 576 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

Internal protein sequence analysis: Enzymatic digestion for less than 10 μg of protein bound to polyvinylidene difluoride or nitrocellulose membranes

1992 • 290 citations

Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells

1991 • 256 citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

1990 • 247 citations

A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression

1993 • 236 citations

Endothelin‐converting enzymes

1992 • 223 citations

Molecular cloning and primary structure of Kell blood group protein.

1991 • 218 citations

Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist.

1993 • 217 citations

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)

1988 • 207 citations

Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat.

1994 • 198 citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

1993 • 168 citations

SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

1994 • 165 citations

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

1991 • 165 citations

Purification and characterization of endothelin-converting enzyme from rat lung.

1993 • 154 citations

The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion

1993 • 153 citations

Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain

1991 • 137 citations

The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide

1994 • 137 citations

Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. OFF.

1993 • 134 citations

Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model

1993 • 123 citations

A Novel Endothelin ETA Receptor Antagonist, BQ-485, and Its Preventive Effect on Experimental Cerebral Vasospasm in Dogs

1993 • 118 citations

Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments.

1992 • 112 citations

Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells

1991 • 78 citations

Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteins^a

1993 • 76 citations

Acute cyclosporine-induced renal vasoconstriction is mediated by endothelin-1.

1993 • 68 citations

Synthesis of Endothelin-1 Analogues, Endothelin-3, and Sarafotoxin S6b

1989 • 58 citations

Effects of BQ-123 on renal function and acute cyclosporine-induced renal dysfunction

1994 • 53 citations

The endothelin-converting enzyme from human umbilical vein is a membrane-bound metalloprotease similar to that from bovine aortic endothelial cells.

1992 • 50 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1993 • 50 citations

A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma

1990 • 44 citations

Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland

1992 • 44 citations

WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

1994 • 43 citations

Identification and Characterization of Endothelin Converting Activity from EAHY-926 Cells: Evidence for the Physiologically Relevant Human Enzyme

1994 • 32 citations

Secretory functions of the vascular endothelium.

1992 • 32 citations

Endothelial cells stimulate aldosterone release from bovine adrenal zona glomerulosa cells

1994 • 27 citations

Endothelin-converting enzymes and other families of metallo-endopeptidases

1993 • 22 citations

Big endothelin‐1 structure important for specific processing by endothelin‐converting enzyme of bovine endothelial cells

1993 • 19 citations

Receptor binding affinity and biological activity of C-terminal elongated forms of endothelin-1

1991 • 15 citations