Cell cycle regulation of human WEE1.

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Inactivation of the p34 ^cdc2 -Cyclin B Complex by the Human WEE1 Tyrosine Kinase

1992 • 688 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1991 • 579 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins.

1993 • 342 citations

Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells

1986 • 328 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

1992 • 276 citations

The cdc25 M-phase inducer: An unconventional protein phosphatase

1992 • 266 citations

Premature chromosome condensation in a ts DNA-mutant of BHK cells

1978 • 260 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

1993 • 247 citations

Activation of human cyclin-dependent kinases in vitro.

1992 • 242 citations

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

1993 • 235 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.

1991 • 218 citations

Wee1+-like gene in human cells

1991 • 211 citations

Nuclear export of proteins: The role of nuclear retention

1993 • 209 citations

Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer

1993 • 184 citations

Two distinct mechanisms for negative regulation of the Wee1 protein kinase.

1993 • 178 citations

Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase

1993 • 161 citations

Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.

1994 • 129 citations

Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein.

1986 • 87 citations

The cell cycle regulator, human p50 , is a tyrosine kinase and not a serine/tyrosine kinase

1992 • 39 citations