Identification of Two Novel Regulatory Elements within the 5′-Untranslated Region of the Human Sγ-Globin Gene

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22

1986 • 455 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

The Molecular Basis of Blood Diseases

1994 • 370 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

1993 • 344 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

DNA sequences necessary for transcription of the rabbit β-globin gene in vivo

1982 • 298 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

Structural arrangements of transcription control domains within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters.

1988 • 271 citations

[66] Mapping of gene transcripts by nuclease protection assays and cDNA primer extension

1987 • 228 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Human γ-globin genes silenced independently of other genes in the β-globin locus

1991 • 191 citations

Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genes.

1992 • 183 citations

The 5′ Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Transcript Is a Potent Translational Inhibitor

1988 • 180 citations

Localization of DNA sequences necessary for transcription of the rabbit β-globin gene in vitro

1981 • 158 citations

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

1990 • 151 citations

Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta-promoter.

1992 • 148 citations

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1992 • 147 citations

Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers.

1993 • 126 citations

The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4.

1989 • 126 citations

A cis-acting element within the 5′ leader of a cytomegalovirus β transcript determines kinetic class

1986 • 125 citations

Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein.

1995 • 117 citations

Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.

1993 • 98 citations

Downstream sequences affect transcription initiation from the adenovirus major late promoter.

1986 • 97 citations

cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor mRNA.

1992 • 81 citations

A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation

1990 • 79 citations

The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation

1992 • 63 citations

Cell-specific expression of the human gastrin gene: evidence for a control element located downstream of the TATA box.

1987 • 45 citations

A rapid method for generating linker scanning mutants utilizing PCR.

1993 • 20 citations