Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis

1987 • 929 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Trafficking of lysosomal enzymes in normal and disease states.

1986 • 445 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Exocytosis regulates urinary acidification in turtle bladder by rapid insertion of H+ pumps into the luminal membrane.

1982 • 316 citations

Isolation of galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque filter hybridization

1979 • 295 citations

Thiol proteases

1985 • 274 citations

Expression ofrasOncogene p21 in Prostate Cancer

1986 • 269 citations

Activation of mouse genes in transformed cells

1983 • 252 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.

1983 • 231 citations

Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

1984 • 223 citations

Action of rat liver cathepsin L on collagen and other substrates.

1982 • 221 citations

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

1983 • 221 citations

Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein

1987 • 206 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

1983 • 186 citations

Elastinolytic activity of human cathepsin L

1986 • 185 citations

Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell.

1985 • 175 citations

Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.

1987 • 163 citations

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

1983 • 161 citations

Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells.

1985 • 159 citations

Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.

1978 • 149 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

The major excreted protein of transformed fibroblasts is an activable acid-protease.

1986 • 147 citations

Principles of Metastasis

1986 • 143 citations

Cloning and characterization of a mouse cysteine proteinase.

1986 • 137 citations

Tumor promoters and kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA

1980 • 130 citations

Experimental metastasis in nude mice of NIH 3T3 cells containing various ras genes.

1986 • 119 citations

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.

1986 • 113 citations

Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.

1984 • 108 citations

Control of exocytosis

1987 • 98 citations

Intracellular protein catabolism: state of the art

1986 • 98 citations

Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region.

1986 • 96 citations

The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.

1986 • 96 citations

Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells.

1986 • 94 citations

Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.

1985 • 89 citations

Uteroferrin has N-asparagine-linked high-mannose-type oligosaccharides that contain mannose 6-phosphate.

1984 • 78 citations

Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways.

1987 • 66 citations

Activities of cathepsins B and L in isolated nephron segments from proteinuric and nonproteinuric rats

1986 • 66 citations

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

1986 • 58 citations

The major ras induced protein in NIH3T3 cells is cathepsin L

1987 • 46 citations

The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line

1986 • 42 citations

Expression of H-ras Correlates with Metastatic Potential: Evidence for Direct Regulation of the Metastatic Phenotype in 10T1/2 and NIH 3T3 Cells

1987 • 41 citations

Activation of the intramyofibral autophagic-lysosomal system in muscular dystrophy.

1987 • 39 citations

Regulation of the Transcript for a Lysosomal Protein: Evidence for a Gene Program Modified by Platelet-Derived Growth Factor

1985 • 36 citations

Cellular ras oncogene expression and cell cycle measured by flow cytometry in hematopoietic cell lines

1986 • 28 citations

Degradation of Myocardial Structural Proteins in Myocardial Infarcted Dogs is Reduced by Ep459, a Cysteine Proteinase Inhibitor

1986 • 25 citations

Cellular ras oncogene expression and cell cycle measured by flow cytometry in hematopoietic cell lines

1986 • 24 citations

Rat mammary gland in culture secretes a stable high molecular weight form of cathepsin L

1985 • 18 citations