Genetic Manipulation of the IGF-I Axis to Regulate Mammary Gland Development and Function

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Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

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1984 • 906 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

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Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

2000 • 834 citations

Growth Hormone and Bone*

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Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth

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Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation

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A dual effector theory of growth-hormone action

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Insulin-like growth factor binding proteins and their role in controlling IGF actions

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Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

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Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

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Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Mitochondrial Oxidative Stress Plays a Key Role in Aging and Apoptosis

2000 • 382 citations

Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity

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Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.

1994 • 292 citations

Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression

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Endocrine Control of Mammary-Gland Development and Function in the C3H/He Crgl Mouse<xref ref-type="fn" rid="FN1">2</xref>

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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

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1999 • 280 citations

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

2000 • 265 citations

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis

1996 • 256 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 • 232 citations

Insulin-Like Growth Factor I Is Essential for Terminal End Bud Formation and Ductal Morphogenesis during Mammary Development1

1999 • 226 citations

Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas

2001 • 214 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

Apoptosis in the aging process

2000 • 204 citations

Mammary involution in dairy animals.

1999 • 203 citations

Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

2001 • 200 citations

14-3-3 (ϵ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner

1997 • 196 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism

1994 • 186 citations

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studiesin vivoandin vitro

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Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1

2001 • 153 citations

Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid.

1995 • 152 citations

Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis

1996 • 146 citations

Liver-Derived IGF-I is of Importance for Normal Carbohydrate and Lipid Metabolism

2001 • 138 citations

Mammary cell changes during pregnancy and lactation

1993 • 136 citations

Targeted Disruption of the IGF-I Receptor Gene Decreases Cellular Proliferation in Mammary Terminal End Buds

2001 • 129 citations

Increase in milk secretion and mammary blood flow by intra-arterial infusion of insulin-like growth factor-I into the mammary gland of the goat

1990 • 127 citations

Evidence That the Mammary Fat Pad Mediates the Action of Growth Hormone in Mammary Gland Development

1998 • 119 citations

Competition for binding to insulin-like growth factor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs.

1992 • 118 citations

Insulin-like growth factor 1 is required for G ₂ progression in the estradiol-induced mitotic cycle

1999 • 116 citations

The role of prolactin and growth hormone in the regulation of casein gene expression and mammary cell survival: relationships to milk synthesis and secretion.

1996 • 114 citations

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.

1992 • 114 citations

Interactions of prolactin and growth hormone (GH) in the regulation of mammary gland function and epithelial cell survival.

1997 • 106 citations

NON-LACTOGENIC EFFECTS OF GROWTH HORMONE ON GROWTH AND INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC ACID OF RAT MAMMARY GLAND

1990 • 105 citations

Early mammary development: growth hormone and IGF-1.

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14-3-3 Proteins interact with the insulin-like growth factor receptor but not the insulin receptor1

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Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

2000 • 98 citations

Insulin and Insulin-Like Growth Factor-I Stimulate DNA Synthesis in Bovine Mammary Tissue in Vitro

1989 • 92 citations

The Insulin-Like Growth Factors (IGF) and IGF Type I Receptor during Postnatal Growth of the Murine Mammary Gland: Sites of Messenger Ribonucleic Acid Expression and Potential Functions**This work was supported, in part, by NIH Grant DK-48103 (to T.L.W.)

1999 • 86 citations

Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

2001 • 83 citations

Insulin-like growth factor-I-mediated survival from Anoikis: Role of cell aggregation and focal adhesion kinase

1998 • 79 citations

IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.

2000 • 77 citations

Modulation of mammary development and programmed cell death by the frequency of milk removal in lactating goats

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Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells

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Comparison of the Roles of Insulin and Insulin-Like Growth Factor I in Casein Gene Expression and in the Development of α-Lactalbumin and Glucose Transport Activities in the Mouse Mammary Epithelial Cell

1987 • 66 citations

Local IGF-I axis in peripubertal ruminant mammary development.

2000 • 63 citations

Human Insulin-Like Growth Factor I (IGF-I) Produced in the Mammary Glands of Transgenic Rabbits: Yield, Receptor Binding, Mitogenic Activity, and Effects on IGF-Binding Proteins

1997 • 63 citations

A local increase in the mammary IGF-1: IGFBP-3 ratio mediates the mammogenic effects of estrogen and growth hormone

2001 • 61 citations

Does an IGF-binding protein (IGFBP) present in involuting rat mammary gland regulate apoptosis?

1995 • 48 citations

Insulinlike growth factor-1 inhibits cell death induced by cycloheximide in MCF-7 cells: A model system for analyzing control of cell death

1992 • 48 citations

The activity of transcription factor Stat5 responds to prolactin, growth hormone, and IGF-I in rat and bovine mammary explant culture.

2000 • 48 citations

Regulation of Local Synthesis of Insulin-Like Growth Factor-I and Binding Proteins in Mammary Tissue

2000 • 47 citations

Effects of close-arterial (external pudic) infusion of insulin-like growth factor-II on milk yield and mammary blood flow in lactating goats

1994 • 47 citations

Northern and In Situ Hybridization Analyses of the Effects of Somatotropin on Bovine Mammary Gene Expression

1992 • 43 citations

Ontogeny and epithelial–stromal interactions regulate IGF expression in the ovine mammary gland

1998 • 43 citations

Cellular localisation of GH receptor in the bovine mammary gland during mammogenesis, lactation and involution

2000 • 42 citations

METABOLIC ADAPTATIONS IN MOUSE MAMMARY GLAND DURING A NORMAL LACTATION CYCLE AND IN EXTENDED LACTATION

1987 • 39 citations

Comparative mitogenic and galactopoietic effects of IGF-I, IGF-II and DES-3-IGF-I in bovine mammary gland in vitro

1992 • 38 citations

Transgenic Hypersecretion of des(1–3) Human Insulin-Like Growth Factor I in Mouse Milk Has Limited Effects on the Gastrointestinal Tract in Suckling Pups

1999 • 35 citations

Inability of Overexpressed des(1–3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules*

2001 • 32 citations

Several insulin-like growth factor-I analogues and complexes of insulin-like growth factors-I and -II with insulin-like growth factor-binding protein-3 fail to mimic the effect of growth hormone upon lactation in the rat

1994 • 29 citations

Chapter 17 Genetic Approaches for Studying Programmed Cell Death during Development of the Laboratory Mouse

1995 • 26 citations

MAMMARY NUCLEIC ACIDS AND PITUITARY PROLACTIN SECRETION DURING PROLONGED LACTATION IN MICE

1976 • 25 citations

Overexpression of ovine insulin-like growth factor-I stimulates autonomous autocrine or paracrine growth in bovine mammary-derived epithelial cells.

1992 • 20 citations

Comparison of insulin-like growth factor 1 and insulin effects on prolactin-induced lactogenesis in the rabbit mammary gland in vitro

1989 • 19 citations

Insulin-like Growth Factor I Induction of c-myc Expression in Bovine Fibroblasts Can Be Blocked by Antecedent Insulin Receptor Activation

1998 • 11 citations