Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis

1998 • 555 citations

Metabolic Modulation of Acute Myocardial Infarction

1998 • 533 citations

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

1997 • 496 citations

MyoD-Induced Expression of p21 Inhibits Cyclin-Dependent Kinase Activity upon Myocyte Terminal Differentiation

1995 • 416 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

1995 • 397 citations

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

1998 • 395 citations

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

1997 • 375 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Death by Design

1997 • 364 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

1998 • 308 citations

Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I

1998 • 283 citations

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes

1998 • 211 citations

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.

1997 • 207 citations

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

1997 • 201 citations

Insulin-like Growth Factor-I Rapidly Activates Multiple Signal Transduction Pathways in Cultured Rat Cardiac Myocytes

1997 • 200 citations

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

1995 • 101 citations

Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling Pathway

1998 • 88 citations