Apoptosis in the aging process

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

The Aging Immune System: Primer and Prospectus

1996 • 1,166 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.

1991 • 735 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.

1990 • 389 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

The polyproline region of p53 is required to activate apoptosis but not growth arrest

1997 • 318 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis

1990 • 292 citations

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons.

1997 • 286 citations

Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis

1998 • 279 citations

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

1996 • 275 citations

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

1988 • 257 citations

Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax

1998 • 231 citations

Multisite Phosphorylation and the Integration of Stress Signals at p53

1998 • 185 citations

Chondrocyte apoptosis increases with age in the articular cartilage of adult animals

1998 • 183 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

The effect of advanced old age on the neurone content of the cerebral cortex

1983 • 152 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.

1997 • 149 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

Apoptosis related antigen, LeY and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis

1994 • 129 citations

What Does Cell Death Have To Do with Aging?

1997 • 122 citations

Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and alzheimer patients

1997 • 118 citations

Basal DNA damage in individual human lymphocytes with age

1991 • 116 citations

The soluble form of Fas molecule is elevated in parkinsonian brain tissues

1996 • 101 citations

Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: age-associated differences

1998 • 98 citations

Intracellular Calcium, DNase Activity and Myocyte Apoptosis in Aging Fischer 344 Rats

1998 • 96 citations

Increased apoptosis of CD45RO− T cells with aging

1997 • 92 citations

Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice.

1995 • 86 citations

DNA Damage Responses: p53 Induction, Cell Cycle Perturbations, and Apoptosis

1994 • 84 citations

Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors

1997 • 84 citations

Aging and Regulation of Apoptosis

1997 • 82 citations

Apoptosis in the aged dog brain

1996 • 81 citations

The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis1This work was supported by National Institutes of Health Grant AG00424.1

1997 • 80 citations

Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence

1996 • 78 citations

Apoptosis and ageing

1998 • 74 citations

bcl-2 protein expression in aged brain and neurodegenerative diseases

1994 • 71 citations

Apoptosis and Oxidative Stress in the Aging Brain

1996 • 60 citations

Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes.

1997 • 58 citations

Diet Restriction Increases Apoptosis in the Gut of Aging Rats

1998 • 58 citations

Aging: current concepts.

1997 • 52 citations

An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats

1994 • 49 citations

Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia

1998 • 49 citations

Anti‐CD3‐Induced Apoptosis in T‐Cells From Young and Old Mice

1995 • 46 citations

Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats

1997 • 40 citations

Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats

1996 • 39 citations

Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes

1997 • 34 citations

Developmental and aging changes of Bak expression in the human brain

1998 • 27 citations

Life-Long Caloric Restriction Suppresses Age-Associated Fas Expression in the Fischer 344 Rat Kidney

1999 • 23 citations

Susceptibility of hepatocytes to cell death induced by single administration of cycloheximide in young and old F344 rats effect of dietary restriction

1996 • 15 citations

Altered p53 Expression in Early Stages of Chemically Induced Rodent Hepatocarcinogenesis

1998 • 9 citations

Genetic and epigenetic factors that influence the occurrence of spontaneous lymphoid tumors in crosses of mice of high‐ and low‐incidence strains

1986 • 5 citations

C-type virus particles in spontaneous and virus-induced leukemia and malignant lymphomas in mice and rats.

1986 • 5 citations