Insulin-like Growth Factor I Induction of c-myc Expression in Bovine Fibroblasts Can Be Blocked by Antecedent Insulin Receptor Activation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The insulin signaling system.

1994 • 1,733 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Insulin-Like Growth Factor Receptors

1991 • 235 citations

Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: studies of underlying mechanism.

1992 • 228 citations

Insulin action and the insulin signaling network

1995 • 216 citations

Structural and Biological Characterization of Bovine Insulin-Like Growth Factor Binding Protein-3*

1990 • 160 citations

Characterization of the Somatomedin-C/Insulin-Like Growth Factor I (SM-C/IGF-I) Receptor on Cultured Human Fibroblast Monolayers: Regulation of Receptor Concentrations by SM-C/IGF-I and Insulin*

1982 • 154 citations

The role of the IGF‐I receptor in the growth and transformation of mammalian cells

1994 • 151 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

1994 • 145 citations

Insulin‐like growth factors and diabetes

1992 • 113 citations

INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH

1996 • 97 citations

max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors.

1992 • 92 citations

Regulation of insulin-like growth factor binding protein-3 messenger ribonucleic acid expression by insulin-like growth factor I.

1992 • 83 citations

Interaction of Insulin-Like Growth Factors with a Nonfusing Mouse Muscle Cell Line: Binding, Action, and Receptor Down-Regulation*

1984 • 79 citations

Regulation of Insulin-Like Growth Factor (IGF)-Binding Protein Synthesis by Insulin and IGF-I in Cultured Bovine Fibroblasts*

1990 • 67 citations

The signaling potential of the receptors for insulin and insulin‐like growth factor I (IGF‐I) in 3t3‐l1 adipocytes: Comparison of glucose transport activity, induction of oncogene c‐fos, glucose transporter mRNA, and DNA‐synthesis

1991 • 60 citations

Effect of glucocorticoid on insulin-like growth factor (IGF) regulation of IGF-binding protein expression in fibroblasts.

1995 • 58 citations

Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors.

1990 • 50 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin- like growth factor-I (IGF-I) receptor in IGF-I action

1994 • 50 citations

Insulin-Like Growth Factor I Induces c-fos Messenger Ribonucleic Acid in L6 Rat Skeletal Muscle Cells*

1987 • 49 citations

Regulation of c-fos, c-jun,jun-B, and c-mycMessenger Ribonucleic Acids by Gonadotropin and Growth Factors in Cultured Pig Leydig Cell^*

1991 • 48 citations

Intracellular signaling by growth factors

1995 • 40 citations

Enhanced expression of cyclin D1 in senescent human fibroblasts

1995 • 39 citations

Phosphorylation of insulin-like growth factor I receptor by the insulin receptor tyrosine kinase in intact cultured skeletal muscle cells

1988 • 36 citations

Time of c-fos and c-myc expression in human diploid fibroblasts stimulated to proliferate after prolonged periods in quiescence.

1987 • 34 citations

Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.

1991 • 33 citations

Retinoic Acid Inhibition of Insulin-like Growth Factor I Stimulation of c-fos mRNA Levels in a Breast Carcinoma Cell Line

1994 • 26 citations

Insulin and Interleukin-4 Induce Desensitization to the Mitogenic Effects of Insulin-like Growth Factor-I

1997 • 22 citations

Insulin-Like Growth Factor-Mediated Phosphorylation and Protooncogene Induction in Madin-Darby Canine Kidney Cells

1991 • 20 citations

Requirements of the secondary structures in the primary transcript for multicopy single-stranded DNA synthesis by reverse transcriptase from bacterial retron-Ec107.

1994 • 15 citations

Physiological Concentrations of Insulin Induce Cellular Desensitization to the Mitogenic Effects of Insulin-Like Growth Factor I

1994 • 11 citations

Glucocorticoid modulation of transformed cell proliferation is oncogene specific and correlates with effects on c-myc levels.

1992 • 11 citations

Insulin receptor is phosphorylated in response to treatment of HepG2 cells with insulin-like growth factor I

1990 • 9 citations

Regulation of c-fos expression by IGF-I in bovine chromaffin cells: desensitization following cholinergic activation

1994 • 7 citations