Human Insulin-Like Growth Factor I (IGF-I) Produced in the Mammary Glands of Transgenic Rabbits: Yield, Receptor Binding, Mitogenic Activity, and Effects on IGF-Binding Proteins

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

1986 • 231 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.

1990 • 148 citations

Clinical Uses of Insulin-like Growth Factor I

1994 • 138 citations

Anabolic effects of recombinant insulin-like growth factor-I in cachectic patients with the acquired immunodeficiency syndrome.

1994 • 132 citations

Characterization of the affinities of insulin-like growth factor (IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs.

1993 • 129 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

Insulin-Like Growth Factor (IGF) Binding to Cell Monolayers Is Directly Modulated by the Addition of IGF-Binding Proteins*

1991 • 102 citations

Maternal and neonatal somatomedin C/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig

1988 • 101 citations

A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1)

1989 • 101 citations

Acquired Growth Hormone Resistance in Patients with Hypercatabolism

1993 • 98 citations

Characterization of a Specific Receptor for Somatomedin C (SM-C) on Cultured Human Lymphocytes: Evidence that SM-C Modulates Homologous Receptor Concentration*

1980 • 97 citations

Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows.

1991 • 95 citations

Trophic Support of Motoneurons: Physiological, Pathophysiological, and Therapeutic Implications

1993 • 84 citations

Body Fat in Laron Syndrome Patients: Effect of Insulin-Like Growth Factor I Treatment

1993 • 81 citations

Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I

1993 • 79 citations

Recombinant insulin‐like growth factor binding protein‐1 inhibits IGF‐I, serum, and estrogen‐dependent growth of MCF‐7 human breast cancer cells

1993 • 78 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

Valid measurements of total IGF concentrations in biological fluids. Recommendations from the 3rd International Symposium on Insulin-like Growth Factors

1994 • 71 citations

Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits

1994 • 71 citations

Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women

1993 • 69 citations

Anabolic effects of recombinant insulin-like growth factor-I in cachectic patients with the acquired immunodeficiency syndrome

1994 • 69 citations

Insulin-Like Growth Factors I and II and Their Binding Proteins in Rat Milk

1991 • 68 citations

Insulin-Like Growth Factor-1 Therapy in Diabetes: Physiologic Basis, Clinical Benefits, and Risks

1994 • 62 citations

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3.

1993 • 62 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

1994 • 55 citations

Short-term effects of recombinant human insulin-like growth factor I on metabolic control of patients with type II diabetes mellitus.

1993 • 52 citations

Laron syndrome due to a post-receptor defect: response to IGF-I treatment.

1993 • 46 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression

1996 • 44 citations

Receptor-Mediated Endocytosis and Lysosomal Processing of Insulin-Like Growth Factor I by Mitogenically Responsive Cells*

1988 • 42 citations

New data on the proteins of rabbit (Oryctolagus cuniculus) milk

1995 • 38 citations

Characterization of the affinities of insulin-like growth factor (IGF)- binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs

1993 • 38 citations

Short-term effects of recombinant human insulin-like growth factor I on metabolic control of patients with type II diabetes mellitus

1993 • 31 citations

Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I

1993 • 30 citations

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3

1993 • 27 citations

Mammary gland specific expression of chymosin constructs in transgenic rabbits

1995 • 21 citations

O2 activation in cytochrome oxidase and in other heme proteins

1992 • 20 citations

Formation-stimulating regimens other than sodium fluoride

1993 • 18 citations

IGFs: function and clinical importance 5 Therapeutic potential of rhIGF-I in diabetes and conditions of insulin resistance

1993 • 13 citations

Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

1986 • 12 citations

Insulin-like growth factor 1 and endotoxin-mediated kidney dysfunction in critically ill, parenterally fed rats.

1993 • 10 citations

Deleted Work

1955 • 0 citations