Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

p53 Mutations in Human Cancers

1991 • 8,133 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Gain of function mutations in p53

1993 • 876 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.

1995 • 318 citations

The Physiopathology of Cancer

1959 • 312 citations

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

1997 • 305 citations

Friend virus-induced erythroleukemia and the multistage nature of cancer

1991 • 249 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression

1996 • 230 citations

Insulin-like Growth Factor-binding Protein (IGFBP-3) Predisposes Breast Cancer Cells to Programmed Cell Death in a Non-IGF-dependent Manner

1997 • 219 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

1998 • 151 citations

Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis

1996 • 146 citations

Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

1996 • 144 citations

Insulin-Like Growth Factor (IGF)-Binding Protein-3 Blocks IGF-I-Induced Receptor Down-Regulation and Cell Desensitization in Cultured Bovine Fibroblasts*

1991 • 130 citations

neu/ERBB2 Cooperates with p53-172H during Mammary Tumorigenesis in Transgenic Mice

1997 • 107 citations

DNA double-strand breaks, chromosomal rearrangements, and genomic instability

1998 • 104 citations

Early mammary development: growth hormone and IGF-1.

1997 • 104 citations

Interference of the IGF system as a strategy to inhibit breast cancer growth

1992 • 100 citations

A transgenic mouse model for mammary carcinogenesis

1998 • 93 citations

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

1998 • 87 citations

Regulation of insulin-like growth factor binding protein-3 messenger ribonucleic acid expression by insulin-like growth factor I.

1992 • 83 citations

cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins

1994 • 79 citations

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice.

1998 • 68 citations

Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development.

1993 • 63 citations

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice

1998 • 57 citations

Insulin and insulin-like growth factor-I regulate hepatic insulin-like growth factor binding protein-3 by different mechanisms.

1996 • 45 citations

Mutant p53 proteins behave in a dominant, negative fashion in vivo.

1994 • 45 citations

Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and IGF-1 genes.

1988 • 20 citations

Loss of cell cycle controls in apoptotic lymphoblasts of the bursa of Fabricius.

1994 • 15 citations