Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

1994 • 969 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

Wnt genes

1992 • 799 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

The oncogenic activation of β-catenin

1999 • 655 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

1999 • 613 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

An entire functional mammary gland may comprise the progeny from a single cell

1998 • 544 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

2000 • 476 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Signal transduction by β-catenin

1995 • 398 citations

Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

1999 • 278 citations

Think globally, act locally: the making of a mouse mammary gland

1998 • 269 citations

Postnatal Development of the Rodent Mammary Gland

1987 • 266 citations

Precocious Mammary Gland Development in P-Cadherin–deficient Mice

1997 • 252 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

Cytoskeleton—membrane interactions

1996 • 231 citations

γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin

2000 • 223 citations

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

1995 • 194 citations

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

1990 • 188 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis

1998 • 183 citations

Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in Xenopus

1997 • 177 citations

Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System

1997 • 157 citations

Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin.

1996 • 151 citations

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

1997 • 145 citations

Developmental and Hormonal Regulation of Wnt Gene Expression in the Mouse Mammary Gland

1995 • 143 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

Desmosomal Cadherin Binding Domains of Plakoglobin

1996 • 122 citations

Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo

2000 • 118 citations

Estrogen and progestin regulation of cell cycle progression.

1998 • 117 citations

The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-myc and Cyclin D1 in Transformation of Multiple Tissues

2000 • 93 citations

Plakoglobin Regulates the Expression of the Anti-apoptotic Protein BCL-2

2000 • 92 citations

Side-branching in the mammary gland: the progesterone–Wnt connection

2000 • 89 citations

Mammary Embryogenesis

1987 • 88 citations

Compartment switching of WNT-2 expression in human breast tumors.

1996 • 84 citations

Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

1999 • 82 citations

Localization and Quantification of Wnt-2 Gene Expression in Mouse Mammary Development

1993 • 80 citations

Axin Directly Interacts with Plakoglobin and Regulates Its Stability

1999 • 80 citations

A β-catenin/engrailed chimera selectively suppresses Wnt signaling

2000 • 69 citations

Cytoplasmically Anchored Plakoglobin Induces a WNT-like Phenotype inXenopus

1997 • 69 citations

A comparative evaluation of β-catenin and plakoglobin signaling activity

2000 • 65 citations

Plakoglobin and β-Catenin: Distinct But Closely Related

1992 • 62 citations

Accumulation of Armadillo Induced by Wingless, Dishevelled, and Dominant-negative Zeste-white 3 Leads to Elevated DE-cadherin inDrosophila Clone 8 Wing Disc Cells

1997 • 57 citations

Expression of the Cytoplasmic Domain of E-cadherin Induces Precocious Mammary Epithelial Alveolar Formation and Affects Cell Polarity and Cell–Matrix Integrity

1999 • 44 citations

Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors.

1992 • 42 citations

Retinoic acid alters the keratinization of cultured rat sublingual keratinocytes in vitro

1987 • 3 citations