Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

IGF-I is required for normal embryonic growth in mice.

1993 • 810 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

1976 • 415 citations

Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.

1989 • 320 citations

Recombinant Human Insulin-Like Growth Factor I Increases Insulin Sensitivity and Improves Glycemic Control in Type II Diabetes

1996 • 283 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action

1986 • 232 citations

Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1.

1991 • 221 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway

1999 • 207 citations

Insulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transgenic Mice

1998 • 185 citations

Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.

1993 • 170 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Physiology of Growth Hormone Secretion and Action

1992 • 169 citations

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors.

1975 • 152 citations

Trial of Insulinlike Growth Factor I Therapy for Patients With Extreme Insulin Resistance Syndromes

1993 • 145 citations

Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.

1992 • 135 citations

The Combination of Insulin-Like Growth Factor I and Insulin-Like Growth Factor-Binding Protein-3 Reduces Insulin Requirements in Insulin-Dependent Type 1 Diabetes: Evidence forin VivoBiological Activity¹

2000 • 129 citations

Insulin-Like Growth Factor-I at Physiological Concentrations Is a Potent Inhibitor of Insulin Secretion*

1990 • 127 citations

TRANSGENIC MODELS OF GROWTH HORMONE ACTION

1999 • 121 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular Signaling

1996 • 120 citations

Identification of Enhanced Serine Kinase Activity in Insulin Resistance

1999 • 107 citations

Changes in the circulating IGF system during short-term fasting and refeeding in rats

1999 • 103 citations

Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4

1997 • 101 citations

Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.

1994 • 97 citations

Insulin-like Growth Factor I: Physiology, Metabolic Effects and Clinical Uses

1996 • 80 citations

Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats.

1992 • 79 citations

The Combination of Insulin-Like Growth Factor I and Insulin-Like Growth Factor-Binding Protein-3 Reduces Insulin Requirements in Insulin-Dependent Type 1 Diabetes: Evidence for in VivoBiological Activity

2000 • 76 citations

Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice

1999 • 71 citations

Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues

1997 • 63 citations

Genetic engineering in mice: impact on insulin signalling and action

1998 • 58 citations

Trial of insulinlike growth factor I therapy for patients with extreme insulin resistance syndromes

1993 • 52 citations

Growth Hormone Insulin-Like Growth Factor I Axis in Insulin-Dependent Diabetes mellitus

1996 • 42 citations

JAK1-dependent Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) Is Inhibited by IRS-1 Serine Phosphorylation

1999 • 41 citations

Effects of Antagonists of Growth Hormone-Releasing Hormone (GHRH) on GH and Insulin-Like Growth Factor I Levels in Transgenic Mice Overexpressing the Human GHRH Gene, an Animal Model of Acromegaly*

1997 • 41 citations

IGF-I and diabetes in adolescence.

1998 • 33 citations

Insulin-like growth factor I inhibits glucose-stimulated insulin secretion but does not impair glucose metabolism in normal humans.

1993 • 32 citations

Growth factor control of pancreatic B cell hyperplasia

1991 • 32 citations

Effects of acute and chronic administration of a new potent antagonist of growth hormone-releasing hormone in rats: mechanisms of action.

1996 • 28 citations

Metabolic Effects of Hypopituitarism and Acromegaly<sup>1</sup>

1991 • 28 citations

Inhibition of GH Release in Rats by New Potent Antagonists of Growth Hormone-Releasing Hormone (GH-RH)

1997 • 18 citations

Suppression of insulin-like growth factor I during epidermal growth factor-induced growth retardation

1991 • 11 citations

Different Effects of the GABAergic Agent Sodium Valproate on the Oxytocin Responses to Angiotensin II and Insulin-Induced Hypoglycemia in Normal Men

1991 • 5 citations

The crucial role of a phosphatase in insulin resistance and obesity

1999 • 4 citations