Development, trafficking, and function of memory T‐cell subsets

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Dendritic-cell trafficking to lymph nodes through lymphatic vessels

2005 • 1,071 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Duration of antiviral immunity after smallpox vaccination

2003 • 901 citations

Cytokine control of memory T-cell development and survival

2003 • 885 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Regulation of Dendritic Cell Migration to the Draining Lymph Node

2003 • 863 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

2003 • 599 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

2005 • 489 citations

T cell fitness determined by signal strength

2003 • 478 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

2005 • 458 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7

1997 • 405 citations

Herpes Simplex Virus-Specific Memory CD8+ T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia

2003 • 393 citations

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

2005 • 382 citations

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

2004 • 371 citations

Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells

1999 • 367 citations

Control of T Cell Viability

2004 • 367 citations

Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells

2005 • 363 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites

2004 • 348 citations

Jump-starting the immune system: prime–boosting comes of age

2003 • 338 citations

Chemokines in the systemic organization of immunity

2003 • 335 citations

CD8+ T cell contraction is controlled by early inflammation

2004 • 322 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

Evolution of innate and adaptive immunity: can we draw a line?

2004 • 305 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Activated Primary and Memory CD8 T Cells Migrate to Nonlymphoid Tissues Regardless of Site of Activation or Tissue of Origin

2004 • 282 citations

CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

2003 • 279 citations

Differential contributions of central and effector memory T cells to recall responses

2005 • 275 citations

Bone Marrow Is a Preferred Site for Homeostatic Proliferation of Memory CD8 T Cells

2005 • 273 citations

The bone marrow: a nest for migratory memory T cells

2005 • 271 citations

Homing Receptors and the Control of Lymphocyte Migration

1986 • 265 citations

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.

1996 • 259 citations

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

2005 • 249 citations

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice

2003 • 241 citations

Down-regulation of homing receptors after T cell activation.

1988 • 235 citations

L-selectin: mechanisms and physiological significance of ectodomain cleavage

2005 • 235 citations

MyD88-Dependent but Toll-Like Receptor 2-Independent Innate Immunity to Listeria: No Role for Either in Macrophage Listericidal Activity

2002 • 235 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

An improved method of parabiosis

1933 • 221 citations

Maintenance, Loss, and Resurgence of T Cell Responses During Acute, Protracted, and Chronic Viral Infections

2004 • 214 citations

T Cell Death and Memory

2001 • 204 citations

CD8+ Memory T Cells (CD44high, Ly-6C+) Are More Sensitive than Naive Cells (CD44low, Ly-6C−) to TCR/CD8 Signaling in Response to Antigen

1998 • 177 citations

Cutting Edge: Transpresentation of IL-15 by Bone Marrow-Derived Cells Necessitates Expression of IL-15 and IL-15Rα by the Same Cells

2004 • 175 citations

Mechanisms of L-selectin regulation by activated T cells.

1997 • 174 citations

Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface.

1990 • 168 citations

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

2003 • 162 citations

Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice.

1992 • 161 citations

IL-15Rα expression on CD8⁺T cells is dispensable for T cell memory

2003 • 160 citations

Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells

2004 • 159 citations

Developmental Regulation of Lck Targeting to the CD8 Coreceptor Controls Signaling in Naive and Memory T Cells

1999 • 155 citations

Leukocyte Migration Is Regulated by L-Selectin Endoproteolytic Release

2003 • 154 citations

The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

2003 • 154 citations

Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.

1996 • 153 citations

Induction and Visualization of Mucosal Memory CD8 T Cells Following Systemic Virus Infection

1999 • 143 citations

CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow

2005 • 134 citations

Complex Memory T-Cell Phenotypes Revealed by Coexpression of CD62L and CCR7

2005 • 128 citations

T cell immunity in lymphoid and non-lymphoid tissues

2002 • 117 citations

IL-15 Regulates CD8+ T Cell Contraction during Primary Infection

2006 • 112 citations

IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization

2005 • 103 citations

Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine (IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells

2005 • 98 citations

Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity

1999 • 98 citations

Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes

2005 • 92 citations

Cutting Edge: Virus-Specific CD4+ Memory T Cells in Nonlymphoid Tissues Express a Highly Activated Phenotype

2002 • 92 citations

Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep

1996 • 90 citations

Single-cell analysis of signal transduction in CD4 T cells stimulated by antigenin vivo

2001 • 78 citations

Differential TCR signaling and the generation of memory T cells.

1998 • 71 citations

Listeria-Infected Myeloid Dendritic Cells Produce IFN-β, Priming T Cell Activation

2005 • 68 citations

Differential SLP-76 Expression and TCR-Mediated Signaling in Effector and Memory CD4 T Cells

2002 • 62 citations

Properties of murine CD8+CD27- T cells

2005 • 61 citations

Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells

1998 • 60 citations

Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine

2000 • 55 citations

Close encounters of the first and second kind: T–DC and T–B interactions in the lymph node

2005 • 54 citations

Immunological memory to viral infection

2004 • 51 citations

Sustained Response Initiation Is Required for T Cell Clonal Expansion But Not for Effector or Memory Development In Vivo

2003 • 45 citations

Stability of Naive and Memory Phenotypes on Resting CD4 T Cells In Vivo

1999 • 37 citations

The CD8 memory T cell subsystem: Integration of homeostatic signaling during migration

2005 • 31 citations

Kinetics and clonality of immunological memory in humans

2004 • 21 citations

The Formation of Complement Fixing and Neutralizing Antibodies After the Injection of Inactivated Rabies Virus with Adjuvants

1950 • 12 citations

Reversibility of Loss of Homing Receptor Expression Following Activation

1988 • 11 citations