Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Asymmetric and symmetric stem-cell divisions in development and cancer

2006 • 1,361 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

2005 • 953 citations

Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

2004 • 890 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

The PAR-aPKC system: lessons in polarity

2006 • 676 citations

Cancer stem cells: lessons from leukemia

2005 • 610 citations

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

2003 • 599 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

2004 • 537 citations

IFN-γ production by antigen-presenting cells: mechanisms emerge

2001 • 456 citations

Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates

2004 • 444 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

2004 • 354 citations

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

2006 • 323 citations

Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo

2005 • 322 citations

Notch signaling is an important regulator of type 2 immunity

2005 • 282 citations

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

2005 • 271 citations

Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

2001 • 264 citations

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

2006 • 263 citations

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

2005 • 255 citations

A role for the immunological synapse in lineage commitment of CD4 lymphocytes

2004 • 180 citations

CD4 T cells integrate signals delivered during successive DC encounters in vivo

2005 • 158 citations

Control of T helper 2 cell function and allergic airway inflammation by PKCζ

2005 • 89 citations

Cutting Edge: In Vivo Identification of TCR Redistribution and Polarized IL-2 Production by Naive CD4 T Cells

2001 • 83 citations

The c-SMAC

2005 • 75 citations

Dynamic Changes During the Immune Response in T Cell–Antigen-presenting Cell Clusters Isolated from Lymph Nodes

2003 • 65 citations

The Notch Regulator Numb Links the Notch and TCR Signaling Pathways

2005 • 53 citations