Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

Sensitization and Antibody Formation after Injection of Tubercle Bacilli and Paraffin Oil.

1937 • 311 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

1993 • 256 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity

1998 • 160 citations

Effectiveness of Lipid and Lipidophilic Substances as Adjuvants

1961 • 148 citations

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.

1999 • 141 citations

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

1994 • 126 citations

Antibody-IL-12 Fusion Proteins Are Effective in SCID Mouse Models of Prostate and Colon Carcinoma Metastases

1998 • 93 citations

Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6.

1989 • 90 citations

Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.

1996 • 88 citations

Immunological tolerance: Danger – pathogen on the premises!

1996 • 86 citations

Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12.

1998 • 65 citations

Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.

1997 • 61 citations

Interleukin 12 gene therapy of MHC-negative murine melanoma metastases.

1998 • 56 citations

Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor.

1997 • 49 citations

Tolerant CD8 T Cells Induced by Multiple Injections of Peptide Antigen Show Impaired TCR Signaling and Altered Proliferative Responses In Vitro and In Vivo

1998 • 49 citations

High Frequency of Specific CD8+ T Cells in the Tumor and Blood Is Associated with Efficient Local IL-12 Gene Therapy of Cancer

1999 • 47 citations

Antigen- and Lectin-Sensitized Murine Cytolytic T Lymphocyte-Precursors Require Both Interleukin 2 and Endogenously Produced Immune (γ) Interferon for Their Growth and Differentiation into Effector Cells

1986 • 23 citations

Selective induction of growth factor production and growth factor receptor expression by different signals to a single t cell

1989 • 22 citations