Direct Interferon-γ Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

2004 • 1,284 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

IFN-γ production by antigen-presenting cells: mechanisms emerge

2001 • 456 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

Interferon γ Is Required for Activation-induced Death of T Lymphocytes

2002 • 423 citations

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

2005 • 420 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

2005 • 382 citations

Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

1998 • 380 citations

What messenger RNA capping tells us about eukaryotic evolution

2002 • 351 citations

Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

2001 • 349 citations

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells

2000 • 340 citations

CD8+ T cell contraction is controlled by early inflammation

2004 • 322 citations

Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

2005 • 314 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Inflaming the CD8+ T Cell Response

2006 • 243 citations

Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection

2005 • 220 citations

Maintenance, Loss, and Resurgence of T Cell Responses During Acute, Protracted, and Chronic Viral Infections

2004 • 214 citations

Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses

2001 • 207 citations

Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection

2006 • 206 citations

The role of programming in memory T-cell development

2004 • 195 citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

2006 • 186 citations

A role for the immunological synapse in lineage commitment of CD4 lymphocytes

2004 • 180 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

Persistent Virus Infection despite Chronic Cytotoxic T-Lymphocyte Activation in Gamma Interferon-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus

2000 • 136 citations

Cutting Edge: Effector Memory CD8+ T Cells Play a Prominent Role in Recall Responses to Secondary Viral Infection in the Lung

2004 • 127 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

Dynamic Regulation of IFN-γ Signaling in Antigen-Specific CD8+ T Cells Responding to Infection

2005 • 94 citations

Immune Responses following Neonatal DNA Vaccination Are Long-Lived, Abundant, and Qualitatively Similar to Those Induced by Conventional Immunization

2000 • 88 citations

Adaptive Immunity and Enhanced CD8+ T Cell Response toListeria monocytogenesin the Absence of Perforin and IFN-γ

2000 • 88 citations

A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections

2002 • 82 citations

Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells

2006 • 77 citations

Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice

1998 • 77 citations

Cutting Edge: Innate Immune Cells Contribute to the IFN-γ-Dependent Regulation of Antigen-Specific CD8+ T Cell Homeostasis

2006 • 64 citations

Interferon γ Enhances Both In Vitro and In Vivo Priming of CD4+ T Cells for IL-4 Production

2004 • 64 citations

Direct Ex Vivo Kinetic and Phenotypic Analyses of CD8⁺T-Cell Responses Induced by DNA Immunization

2000 • 61 citations

The Rapidity with Which Virus-Specific CD8+ T Cells Initiate IFN-γ Synthesis Increases Markedly over the Course of Infection and Correlates with Immunodominance

2004 • 57 citations

Cutting Edge: Early IFN-γ Signaling Directly Enhances Primary Antiviral CD4+ T Cell Responses

2005 • 55 citations

Low-Affinity Cytotoxic T-Lymphocytes Require IFN-γ to Clear an Acute Viral Infection

1997 • 45 citations

Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection

2005 • 41 citations

Effect of Chronic Viral Infection on Epitope Selection, Cytokine Production, and Surface Phenotype of CD8 T Cells and the Role of IFN-γ Receptor in Immune Regulation

2004 • 28 citations

Perforin and IFN-γ do not significantly regulate the virus-specific CD8+ T?cell response in the absence of antiviral effector activity

2004 • 15 citations