Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Blood flow measurements with radionuclide-labeled particles

1977 • 2,072 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

The Sorbitol Pathway and the Complications of Diabetes

1973 • 750 citations

Glycation Products and the Pathogenesis of Diabetic Complications

1992 • 493 citations

Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat

1991 • 395 citations

Hyperglycemic pseudohypoxia and diabetic complications

1993 • 305 citations

Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects

1993 • 298 citations

Regeneration and Repair of Myelinated Fibers in Sural-Nerve Biopsy Specimens from Patients with Diabetic Neuropathy Treated with Sorbinil

1988 • 298 citations

Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits

1991 • 283 citations

Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats

1994 • 244 citations

The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications

1994 • 234 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Nerve Blood Flow and Oxygen Delivery In Normal, Diabetic, and Ischemic Neuropathy

1989 • 212 citations

The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.

1994 • 205 citations

Determination of monosaccharides as aldononitrile, O-methyloxime, alditol, and cyclitol acetate derivatives by gas chromatography

1984 • 204 citations

Vascular factors in diabetic neuropathy

1994 • 199 citations

Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity

1984 • 178 citations

Pathology and pathogenetic mechanisms of diabetic neuropathy

1995 • 177 citations

Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat

1993 • 148 citations

A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy

1990 • 142 citations

Inhibition of Sorbitol Dehydrogenase: Effects on Vascular and Neural Dysfunction in Streptozocin-Induced Diabetic Rats

1995 • 141 citations

Sorbitol, osmoregulation, and the complications of diabetes.

1988 • 141 citations

Abnormal glutathione metabolism and increased cytotoxicity caused by H2O2 in human umbilical vein endothelial cells cultured in high glucose medium

1994 • 124 citations

Effect of Prostaglandin E1 Analogue TFC 612 on Diabetic Neuropathy in Streptozocin-Induced Diabetic Rats Comparison With Aldose Reductase Inhibitor ONO 2235

1989 • 123 citations

Reversal, by treatment with an aldose reductase inhibitor, of impaired axonal transport and motor nerve conduction velocity in experimental diabetes mellitus

1982 • 116 citations

Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

1995 • 115 citations

Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: Dose-response considerations and independence from a myo-inositol mechanism

1994 • 110 citations

Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs

1994 • 107 citations

Effects of Long-Term Aldose Reductase Inhibition on Development of Experimental Diabetic Neuropathy: Ultrastructural and Morphometric Studies of Sural Nerve in Streptozocin-Induced Diabetic Rats

1990 • 107 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

1992 • 105 citations

The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

1986 • 102 citations

Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl-<scp>L</scp>-Carnitine

1994 • 101 citations

Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats

1996 • 96 citations

Pharmacological manipulation of vascular endothelium function in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization

1993 • 84 citations

Novel Spirosuccinimide Aldose Reductase Inhibitors Derived from Isoquinoline-1,3-diones: 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(11H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and Congeners. 1

1994 • 82 citations

Effects of Polyol-Pathway Inhibition and Dietary myo-Inositol on Glomerular Hemodynamic Function in Experimental Diabetes Mellitus in Rats

1991 • 76 citations

Nerve ischaemia in diabetic rats: time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models

1994 • 75 citations

Angiotensin II receptor blockade improves nerve function, modulates nerve blood flow and stimulates endoneurial angiogenesis in streptozotocin-diabetic ratsand nerve function

1993 • 70 citations

Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy

1993 • 68 citations

Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235

1989 • 68 citations

The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats

1994 • 68 citations

Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats

1985 • 67 citations

Withdrawal of the aldose reductase inhibitor tolrestat in patients with diabetic neuropathy: Effect on nerve function

1993 • 64 citations

The effect of aldose reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus

1991 • 61 citations

Changes in Skeletal Muscle Contractile Properties in Streptozocin-Induced Diabetic Rats and Role of Polyol Pathway and Hypoinsulinemia

1990 • 54 citations

Cellular and Vessel Wall Morphology of Cerebral Cortical Arterioles after Short-Term Diabetes in Adult Rats

1985 • 51 citations

Rapid reversal by aminoguanidine of the neurovascular effects of diabetes in rats: Modulation by nitric oxide synthase inhibition

1996 • 48 citations

Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve

1994 • 47 citations

Effects of the sulphydryl donor N‐acetyl‐L‐cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats

1996 • 45 citations

Regional blood flow in resting and stimulated sciatic nerve of diabetic rats

1988 • 43 citations

Polyol pathway‐related skeletal muscle contractile and morphological abnormalities in diabetic rats

1993 • 42 citations

Schwann Cell Injury is Attenuated by Aldose Reductase Inhibition in Galactose Intoxication

1993 • 41 citations

Sorbitol-accumulating pyrimidine derivatives.

1994 • 40 citations

Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition

1989 • 38 citations

Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats

1992 • 37 citations

Vascular and metabolic factors in the pathogenesis of experimental diabetic neuropathy in mature rats

1994 • 34 citations

Muscle and nerve dysfunction in rats with experimental galactosaemia

1992 • 32 citations

Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats

1991 • 32 citations

Peripheral nerve conduction studies in galactose-poisoned rats

1983 • 31 citations

Experimental nerve ischemia and injury produced by cocaine and procaine

1991 • 31 citations

Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine

1994 • 30 citations

Effect of a potent new aldose reductase inhibitor, (5-(3-thienyl)tetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats

1995 • 28 citations

Vascular factors in diabetic neuropathy

1994 • 27 citations

Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat

1993 • 27 citations

Reversal of defective peripheral nerve conduction velocity, nutritive endoneurial blood flow, and oxygenation by a novel aldose reductase inhibitor, WAY-121,509, in streptozotocin-induced diabetic rats

1996 • 25 citations

Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy

1994 • 18 citations

The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats

1988 • 16 citations

Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

1995 • 16 citations

Impaired myelinated fiber regeneration following freeze-injury in rats with streptozotocin-induced diabetes: involvement of the polyol pathway

1995 • 13 citations

Abnormal glutathione metabolism and increased cytotoxicity caused by H 2 O 2 in human umbilical vein endothelial cells cultured in high glucose medium

1994 • 11 citations

The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats

1994 • 8 citations

Dietary myo-inositol supplementation does not prevent retinal and glomerular vascular structural changes in chronically diabetic rats

1993 • 7 citations

Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin

1995 • 5 citations