Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.

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Hyperglycemic Pseudohypoxia and Diabetic Complications

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Glomerular hemodynamics in experimental diabetes mellitus

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Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Glycolytic and oxidative metabolism in relation to retinal function.

1981 • 361 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Retinal blood flow in diabetic retinopathy.

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Mechanisms of retinal and choroidal neovascularization.

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Aldose reductase in diabetic complications of the eye

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Pyruvate‐enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart

1989 • 223 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Altered Retinal Vascular Response to 100% Oxygen Breathing in Diabetes Mellitus

1984 • 194 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

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Retinal circulatory abnormalities in type 1 diabetes.

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The electroretinogram of the isolated rat retina

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Retinal Vascular Autoregulation in Diabetes Mellitus

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Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control.

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Glutathione depletion in the lens of galactosemic and diabetic rats

1988 • 144 citations

Inhibition of Sorbitol Dehydrogenase: Effects on Vascular and Neural Dysfunction in Streptozocin-Induced Diabetic Rats

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Sorbitol pathway in diabetic and galactosemic rat lens

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Metabolic alterations in the human erythrocyte produced by increases in glucose concentration

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BIOCHEMISTRY OF THE RETINA

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Retinal Vascular Autoregulation in Conditions of Hyperoxia and Hypoxia Using the Blue Field Entoptic Phenomenon

1985 • 107 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

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Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl-<scp>L</scp>-Carnitine

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Oxygenation and Vasodilatation in Relation to Diabetic and Other Proliferative Retinopathies

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Hyperglycemia impairs retinal oxygen autoregulation in normal and diabetic dogs.

1983 • 94 citations

The effect of acute hyperglycaemia on the retinal circulation of the normal cat

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Evaluating Retinal Circulation Using Video Fluorescein Angiography in Control and Diabetic Rats

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Effects of Elevated Glucose Concentrations on the Metabolism of the Aortic Wall

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Regulation of glycolysis in the erythrocyte: role of the lactate/pyruvate and NAD/NADH ratios.

1991 • 66 citations

Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.

1990 • 63 citations

NADH-Dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E

1992 • 63 citations

Retinal blood flow by hydrogen clearance polarography in the streptozotocin-induced diabetic rat.

1993 • 60 citations

The Aldose Reductase Controversy

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Effects of very mild versus overt diabetes on vascular haemodynamics and barrier function in rats

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The protective action of pyruvate on recovery of ischemic rat heart: Comparison with other oxidizable substrates

1990 • 53 citations

Oxygen Reactivity in Diabetes Mellitus: Effect of Hypertension and Hyperglycaemia

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[4] Enzymic microdetermination of d-glucose, d-fructose, d-gluconate, 2-keto-d-gluconate, aldehyde, and alcohol with membrane-bound dehydrogenases

1982 • 43 citations

Glucose, glucose-6-phosphate, lactate and pyruvate content of the retina, blood and liver of streptozotocin-diabetic rats fed sucrose- or starch-rich diets

1975 • 41 citations

Sorbitol-accumulating pyrimidine derivatives.

1994 • 40 citations

Alterations in distribution of cardiac output in experimental diabetes in rats

1989 • 39 citations

The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats

1983 • 35 citations

Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.

1994 • 32 citations

Effects of Acute, Subacute, and Chronic Diabetes on Carbohydrate and Energy Metabolism in Rat Sciatic Nerve: Relation to Mechanisms of Peripheral Neuropathy

1995 • 31 citations

Concurrent increases in regional hematocrit and blood flow in diabetic rats: prevention by sorbinil

1992 • 29 citations

Effect of experimental diabetes on glycolytic intermediates and regulation of phosphofructokinase in rat lens

1980 • 26 citations

Responses of the retinal circulation to systemic autonomic stimulation in diabetes mellitus

1989 • 26 citations

Resistance of diabetic rat electroretinogram to hypoxemia.

1993 • 26 citations

Rapid analysis of sorbitol, galactitol, mannitol and myoinositol mixtures from biological sources

1989 • 22 citations

Modulators and milieu in preretinal neovascularisation

1992 • 19 citations

The Efficacy of Aldose Reductase Inhibitors on Polyol Accumulation in Human Lens and Retinal Pigment Epithelium in Tissue Culture

1992 • 18 citations

Lens redox fluorometry: Pyridine nucleotide fluorescence and analysis of diabetic lens

1989 • 14 citations

Reduced and oxidized pyridine nucleotides in the retinae from alloxan-diabetic rats

1962 • 13 citations

Glucose flux and the redox state of pyridine dinucleotides in the rat lens

1988 • 6 citations