Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

Diabetes and cardiovascular disease. The Framingham study

1979 • 4,047 citations

Diabetes and Cardiovascular Disease

1979 • 2,597 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1997 • 1,210 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

Quantitative assessment of atherosclerotic lesions in mice

1987 • 957 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

A Prospective Study of Maturity-Onset Diabetes Mellitus and Risk of Coronary Heart Disease and Stroke in Women

1991 • 664 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

Glucose and diabetic vascular disease ¹

1992 • 372 citations

Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications.

1994 • 351 citations

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

1996 • 340 citations

Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.

1994 • 318 citations

Synthetic low and high fat diets for the study of atherosclerosis in the mouse.

1990 • 291 citations

5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin-dependent diabetic and nondiabetic subjects.

1990 • 291 citations

The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

1996 • 286 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Increased atherosclerosis in streptozotocin-induced diabetic mice.

1996 • 182 citations

Immunological Evidence for the Presence of Advanced Glycosylation End Products in Atherosclerotic Lesions of Euglycemic Rabbits

1995 • 135 citations

Is hyperglycemia associated with cardiovascular disease? The Framingham Study

1991 • 129 citations

Effect of the Antioxidant N,N′ -Diphenyl 1,4-Phenylenediamine (DPPD) on Atherosclerosis in ApoE-Deficient Mice

1995 • 106 citations

The cardiovascular risk associated with impaired glucose tolerance.

1996 • 67 citations

Metabolic Control in 131 Juvenile-onset Diabetic Patients as Measured by HbA1c: Relation to Age, Duration, C-Peptide, Insulin Dose, and One or Two Insulin Injections

1982 • 29 citations