Effects on rat renal osmolytes of extended treatment with an aldose reductase inhibitor

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Predominant osmotically active organic solutes in rat and rabbit renal medullas.

1986 • 382 citations

Glomerular Polyol Accumulation in Diabetes and its Prevention by Oral Sorbinil

1984 • 160 citations

Sorbitol, osmoregulation, and the complications of diabetes.

1988 • 141 citations

Signal for induction of aldose reductase in renal medullary cells by high external NaCl

1989 • 128 citations

Intra- and extracellular element concentrations of rat renal papilla in antidiuresis

1984 • 113 citations

Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis

1989 • 93 citations

A simple HPLC method for quantitating major organic solutes of renal medulla

1989 • 84 citations

Characterization and purification of a mammalian osmoregulatory protein, aldose reductase, induced in renal medullary cells by high extracellular NaCl.

1987 • 77 citations

Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells

1990 • 75 citations

Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil

1984 • 74 citations

Osmotic effectors in kidneys of xeric and mesic rodents: corticomedullary distributions and changes with water availability

1988 • 73 citations

Effects of Sorbinil on Glomerular Structure and Function in Long-Term–Diabetic Rats

1989 • 68 citations

Osmotically active organic solutes in the renal inner medulla

1987 • 68 citations

Localization of aldose and aldehyde reductase in the kidney

1989 • 66 citations

Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats

1991 • 51 citations

Osmotically regulated taurine content in rat renal inner medulla

1991 • 43 citations

Renal Sorbitol Accumulation and Associated Enzyme Activities in Diabetes

1988 • 33 citations

Effects of sorbinil on glomerular structure and function in long-term-diabetic rats

1989 • 30 citations

Feedback inhibition of aldose reductase gene expression in rat renal medulla. Galactitol accumulation reduces enzyme mRNA levels and depletes cellular inositol content.

1990 • 29 citations

Comparison of glucose, sorbitol and fructose accumulation in lens and liver of diabetic and insulin-treated rats and mice

1989 • 24 citations

Intracellular betaine substitutes for sorbitol in protecting renal medullary cells from hypertonicity

1991 • 24 citations

Effects of an aldose reductase inhibitor on organic osmotic effectors in rat renal medulla

1990 • 20 citations

Monoaminoguanidine prevents sorbitol accumulation, nonenzymatic protein glycosylation and development of kidney lesions in diabetic rats

1991 • 9 citations