Interaction between osmotic and oxidative stress in diabetic precataractous lens

Glutathione S-Transferases

1974 • 17,321 citations

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

1972 • 8,501 citations

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

Alpha-lipoic acid as a biological antioxidant

1995 • 1,920 citations

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Cytotoxicity and genotoxicity of lipid-oxidation products

1993 • 802 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

The redox state of free nicotinamide–adenine dinucleotide phosphate in the cytoplasm of rat liver

1969 • 551 citations

The formation of methylglyoxal from triose phosphates

1993 • 533 citations

Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 • 517 citations

Glycation Products and the Pathogenesis of Diabetic Complications

1992 • 493 citations

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

1998 • 344 citations

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

1995 • 309 citations

The role of aldose reductase in the development of diabetic complications

1988 • 293 citations

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

Glutathione content of cultured cells and rodent brain regions: A specific fluorometric assay

1984 • 158 citations

Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats

1997 • 153 citations

Glutathione depletion in the lens of galactosemic and diabetic rats

1988 • 144 citations

The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis

1986 • 143 citations

Sorbitol, osmoregulation, and the complications of diabetes.

1988 • 141 citations

Inhibition of Sorbitol Dehydrogenase: Effects on Vascular and Neural Dysfunction in Streptozocin-Induced Diabetic Rats

1995 • 141 citations

Reversible inactivation of Saccharomyces cerevisiae glutathione reductase under reducing conditions

1984 • 140 citations

Prooxidant-Initiated Lipid Peroxidation in Isolated Rat Hepatocytes: Detection of 4-Hydroxynonenal- and Malondialdehyde-Protein Adducts

1997 • 127 citations

Increased NADH Oxidase Activity in the Retina of the BBZ/WOR Diabetic Rat

1998 • 112 citations

Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens.

1999 • 107 citations

Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens

1995 • 102 citations

The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats

1983 • 95 citations

The Gibbs-Donnan near-equilibrium system of heart

1990 • 94 citations

α-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats

1995 • 93 citations

Influence of methylglyoxal on antioxidant enzymes and oxidative damage

1997 • 89 citations

Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen

1992 • 87 citations

Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-?-lipoic acid

1998 • 77 citations

Aldose reductase inhibitors

2015 • 71 citations

Diabetic and Galactosaemic Cataracts

1984 • 68 citations

The effect of aldose reductase and its inhibition on sugar cataract formation

1986 • 67 citations

[55] High-performance liquid chromatography-electrochemical detection of antioxidants in vertebrate lens: Glutathione, tocopherol, and ascorbate

1994 • 66 citations

Low apparent aldose reductase activity produced by monosaccharide autoxidation

1985 • 61 citations

Nonosmotic Diabetic Cataracts

1990 • 58 citations

Antioxidant Properties of Lipoic Acid and Its Therapeutic Effects in Prevention of Diabetes Complications and Cataracts^a

1994 • 58 citations

Pro-oxidant activation of ocular reductants. 1. Copper and riboflavin stimulate ascorbate oxidation causing lens epithelial cytotoxicity in vitro

1987 • 54 citations

The effect of X-irradiation on cation transport in rabbit lens

1981 • 53 citations

Transport of Circulating Reduced Glutathione at the Basolateral Side of the Anterior Lens Epithelium: Physiologic Importance and Manipulations

1996 • 44 citations

Activation of Aldose Reductase in Rat Lens and Metal-Ion Chelation by Aldose Reductase Inhibitors and Lipoic Acid

1996 • 42 citations

Sorbitol-accumulating pyrimidine derivatives.

1994 • 40 citations

Effect of Sorbitol Dehydrogenase Inhibition on Sugar Cataract Formation in Galactose-fed and Diabetic Rats

1998 • 39 citations

Phosphatase Inhibitors Potentiate 4-Hydroxynonenal-induced Phospholipase D Activation in Vascular Endothelial Cells

1997 • 38 citations

The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil

1990 • 35 citations

Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis

1990 • 28 citations

Effect of experimental diabetes on glycolytic intermediates and regulation of phosphofructokinase in rat lens

1980 • 26 citations

Effect of Sorbitol Dehydrogenase Inhibition on Experimental Diabetic Autonomic Neuropathy

1998 • 26 citations

Bovine and Human α-Crystallins as Molecular Chaperones: Prevention of the Inactivation of Glutathione Reductase by Fructation

1997 • 23 citations

The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment

1998 • 22 citations

Study of the polyol pathway and cell permeability changes in human lens and retinal pigment epithelium in tissue culture.

1992 • 20 citations

Antioxidant status in an in vitro model for hyperglycemic lens cataract formation: Effect of aldose reductase inhibitor statil

1988 • 18 citations

Studies on Diabetic Cataract in Rats Induced by Streptozotocin

1983 • 17 citations

[Glutathione metabolism in erythrocytes from patients with diabetes mellitus].

1991 • 14 citations

Do changes in the hydration of the diabetic human lens precede cataract formation?

1998 • 14 citations

Untersuchungen der Linse, des Blutes und des Kammerwassers von Ratten bei Galaktoseverfütterung

1938 • 13 citations

OXIDATIVE DEFENSE ENZYME ACTIVITY AND mRNA LEVELS IN LENSES OF DIABETIC RATS

1997 • 11 citations

Lens Metabolism and Cellular Effects of Aldose Reductase

1985 • 8 citations

Biochemical changes in lens, aqueous humor and vitreous body and effects of aldose reductase inhibitor (TAT) on rats with experimental diabetes.

1995 • 8 citations

Glucose flux and the redox state of pyridine dinucleotides in the rat lens

1988 • 6 citations

Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs

1997 • 6 citations

Changes in the activity of NADH-oxidase in rat tissues during experimental diabetes.

1994 • 5 citations