Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

Adhesion receptors of the immune system

1990 • 6,585 citations

Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury.

1994 • 495 citations

Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

1991 • 483 citations

Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

1995 • 411 citations

Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.

1991 • 359 citations

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo

1998 • 354 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage.

1994 • 328 citations

Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells

1990 • 293 citations

Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

1993 • 289 citations

Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis.

1993 • 214 citations

Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor.

1997 • 194 citations

In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats.

1998 • 185 citations

Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid.

1997 • 180 citations

Evidence of Polymorphonuclear Neutrophils (PMN) Activation in Patients With Insulin-Dependent Diabetes Mellitus

1987 • 131 citations

Immunohistochemical localization of blood-retinal barrier breakdown in human diabetics.

1989 • 118 citations

Visualization and quantitative analysis of leukocyte dynamics in retinal microcirculation of rats.

1996 • 73 citations

In vivo quantification of leukocyte behavior in the retina during endotoxin-induced uveitis.

1996 • 62 citations

Reperfusion of occluded capillary beds in diabetic retinopathy

1998 • 53 citations

Spontaneous Regression of Neovascularization at the Disk and Elsewhere in Diabetic Retinopathy

1996 • 30 citations

Reflow of obstructed capillaries in the maculae of humans with diabetic retinopathy, observed by fluorescein angiography.

1988 • 19 citations