Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

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A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Calcium's Role in Mechanotransduction during Muscle Development

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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The MAPK signaling cascade

1995 • 3,300 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

2013 • 1,823 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells

1994 • 571 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

1996 • 336 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

1994 • 296 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

1996 • 287 citations

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

1995 • 284 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.

1996 • 240 citations

Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions

1997 • 233 citations

Endothelial Cell Inflammatory Responses to Tumor Necrosis Factor α

1996 • 232 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Role of the Stress-activated/c-Jun NH2-terminal Protein Kinase Pathway in the Cellular Response to Adriamycin and Other Chemotherapeutic Drugs

1996 • 215 citations

Tumor Promotion by Depleting Cells of Protein Kinase Cδ

1997 • 208 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

1997 • 176 citations

Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.

1995 • 175 citations

A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes.

1988 • 171 citations

Normalization of Diacylglycerol-Protein Kinase C Activation by Vitamin E in Aorta of Diabetic Rats and Cultured Rat Smooth Muscle Cells Exposed to Elevated Glucose Levels

1994 • 170 citations

Protein Kinase C δ Inhibits the Proliferation of Vascular Smooth Muscle Cells by Suppressing G1 Cyclin Expression

1997 • 167 citations

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1995 • 158 citations

Thyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive Element

1996 • 154 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.

1994 • 151 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Identification and Characterization of the Cell Type-specific and Developmentally Regulated α7 Integrin Gene Promoter

1996 • 132 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.

1995 • 86 citations

High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells

1995 • 75 citations

Activation of c-Jun-NH2-Kinase by UV Irradiation Is Dependent on p21

1996 • 72 citations

Biochemical Characterization of a Novel KRAS Insertion Mutation from a Human Leukemia

1996 • 62 citations

Anisomycin-Activated Protein Kinases p45 and p55 but Not Mitogen-Activated Protein Kinases ERK-1 and -2 Are Implicated in the Induction of c-fos and c-jun

1994 • 60 citations

Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation.

1995 • 33 citations

Protein Kinase C Isozymes Differentially Regulate Promoters Containing PEA-3/12-O-Tetradecanoylphorbol-13-acetate Response Element Motifs

1996 • 28 citations