The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

2011 • 1,618 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

2008 • 1,184 citations

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

2010 • 1,119 citations

Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

2006 • 1,020 citations

Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

2005 • 1,010 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion

2007 • 910 citations

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

2012 • 857 citations

Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Subverts Tumor Immunity toward a Type 2 Response

2007 • 795 citations

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

2006 • 726 citations

Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression

2007 • 613 citations

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

2010 • 598 citations

Hierarchy of immunosuppressive strength among myeloid‐derived suppressor cell subsets is determined by GM‐CSF

2009 • 542 citations

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

2006 • 531 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.

2003 • 457 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

CD11b+/Gr-1+ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress

2006 • 342 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2—Tumor and Immunological Responses

2012 • 298 citations

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

2005 • 282 citations

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

2004 • 276 citations

Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: Association with tumor-derived growth factors

2006 • 252 citations

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

2011 • 231 citations

The controversial abscopal effect

2005 • 225 citations

Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy

2010 • 225 citations

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

2012 • 207 citations

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

1995 • 169 citations

GM-CSF, IL-1α, IL-β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1α and TNF-α

1994 • 150 citations

Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.

1988 • 150 citations

Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

2010 • 148 citations

Interleukin-1 (22-K factor) induces release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes

1986 • 146 citations

Ly6G+ Neutrophils Are Dispensable for Defense against Systemic Listeria monocytogenes Infection

2011 • 117 citations

In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer

2012 • 100 citations

Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells

2009 • 97 citations

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy

2012 • 92 citations

Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment.

2006 • 88 citations

Anti‐OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer

2008 • 88 citations

Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.

1989 • 67 citations

Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice

2009 • 51 citations

Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer

2012 • 34 citations

Effective treatment of spontaneous metastases derived from a poorly immunogenic murine mammary carcinoma by combined dendritic–tumor hybrid vaccination and adoptive transfer of sensitized T cells

2008 • 31 citations

IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines

1992 • 30 citations

Intrinsic resistance to anticancer agents in the murine pancreatic adenocarcinoma PANC02

1992 • 26 citations

Immunogenicity of an Inactivated Monovalent 2009 Influenza A (H1N1) Vaccine in Patients Who Have Cancer

2012 • 18 citations

Neoadjuvant Immunotherapy Enhances Radiosensitivity Through Natural Killer Cell Activation

2010 • 10 citations