Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

2000 • 2,865 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

2002 • 657 citations

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

1998 • 640 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

<scp>l</scp>-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

2003 • 458 citations

All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.

2003 • 457 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

DNA Vaccination Against Rat Her-2/Neu p185 More Effectively Inhibits Carcinogenesis Than Transplantable Carcinomas in Transgenic BALB/c Mice

2000 • 354 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response

2004 • 334 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

1999 • 307 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: A proof of concept endoscopic study

2003 • 221 citations

Peroxynitrite: reactive, invasive and enigmatic

1999 • 209 citations

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

1995 • 169 citations

Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes

2000 • 155 citations

Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity

2004 • 138 citations

Potential cardioprotective actions of no-releasing aspirin

2002 • 137 citations

Leukocyte, Rather than Tumor-produced SPARC, Determines Stroma and Collagen Type IV Deposition in Mammary Carcinoma

2003 • 132 citations

Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association

2003 • 117 citations

Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma

1998 • 113 citations

Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention.

2003 • 108 citations

IL-1β Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs

2000 • 99 citations

Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats

1999 • 95 citations

NO-donating aspirin inhibits intestinal carcinogenesis in Min (APCMin/+) mice

2003 • 90 citations

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

2001 • 85 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 83 citations

Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice

2002 • 69 citations

Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and TRP-2.

2001 • 69 citations

Aspirin and Salicylates Inhibit the IL-4- and IL-13-Induced Activation of STAT6

2002 • 66 citations

Effective Genetic Vaccination with a Widely Shared Endogenous Retroviral Tumor Antigen Requires CD40 Stimulation during Tumor Rejection Phase

2003 • 43 citations

Effect of a new non‐steroidal anti‐inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils

1995 • 31 citations