Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Tumor heterogeneity and the biology of cancer invasion and metastasis.

1978 • 833 citations

Heterogeneity of tumor cells from a single mouse mammary tumor.

1978 • 582 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

Heparan Sulfate Degradation: Relation to Tumor Invasive and Metastatic Properties of Mouse B16 Melanoma Sublines

1983 • 350 citations

Role of laminin in the attachment and metastasis of murine tumor cells.

1982 • 334 citations

Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

1987 • 315 citations

Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.

1984 • 301 citations

Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.

1983 • 257 citations

Development and Biologic Properties of Malignant Cell Sublines and Clones of a Spontaneously Metastasizing Rat Mammary Adenocarcinoma<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 253 citations

Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

1978 • 248 citations

A simple quantitative assay for studying the invasive potential of high and low human metastatic variants

1987 • 243 citations

A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1984 • 231 citations

Specificity of arrest, survival, and growth of selected metastatic variant cell lines.

1978 • 203 citations

Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.

1981 • 195 citations

Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells.

1986 • 172 citations

Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system.

1982 • 171 citations

Principles of metastasis

1985 • 160 citations

Correlation between circulating cancer cells and incidence of metastases

1983 • 149 citations

Organ specificity of metastatic tumor colonization is related to organ‐selective growth properties of malignant cells

1986 • 145 citations

Cancer metastasis is selective or random depending on the parent tumour population

1982 • 143 citations

Relationship Between Metastatic Potential and Resistance to Natural Killer Cellmediated Cytotoxicity in Three Murine Tumor Systems2, 3

1981 • 142 citations

Selection and Biologic Properties of Malignant Variants of a Murine Lymphosarcoma<xref ref-type="fn" rid="FN2">2</xref>

1978 • 138 citations

Correlation of Growth Capacity of Human Tumor Cells in Hard Agarose With Their In Vivo Proliferative Capacity at Specific Metastatic Sites

1989 • 135 citations

Adhesion characteristics of murine metastatic and nonmetastatic tumor cells in vitro.

1980 • 133 citations

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

1983 • 131 citations

Characterization of metastatic clones derived from a metastatic variant of mouse colon adenocarcinoma 26.

1983 • 130 citations

Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements.

1986 • 116 citations

Differential expression of endogenous lectins on the surface of nontumorigenic, tumorigenic, and metastatic cells.

1986 • 104 citations

Ultrastructural differences in junctional intercellular communication between highly and weakly metastatic clones derived from rat mammary carcinoma.

1990 • 104 citations

Differences in Resistance of Metastatic Tumor Cells and Cells From Local Tumor Growth to Cytotoxicity of Natural Killer Cells<xref ref-type="fn" rid="FN2">2</xref>

1979 • 101 citations

Response of Syngeneic Murine Lymphomata to Immunotherapy in Relation to the Antigenicity of the Tumour

1972 • 99 citations

Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity.

1991 • 97 citations

Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations.

1988 • 97 citations

Metastatic potential of murine fibrosarcoma cells is influenced by cell surface laminin

1984 • 96 citations

Malignant melanoma cell lines selected in vitro for increased homotypic adhesion properties have increased experimental metastatic potential

1986 • 87 citations

Tumor subpopulation interactions in metastasis.

1983 • 82 citations

Metastatic inefficiency in mice bearing B16 melanomas

1982 • 79 citations

A model system for studying metastasis using the embryonic chick.

1982 • 78 citations

The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells.

1991 • 76 citations

Preferential growth of mammary tumors in intact mammary fatpads.

1981 • 75 citations

Dominance of a tumor subpopulation line in mixed heterogeneous mouse mammary tumors.

1988 • 72 citations

Escape of metastasizing clonal tumor cell variants from tumor-specific cytolytic T lymphocytes.

1981 • 64 citations

Heterogeneity in a spontaneous mouse lung carcinoma: Selection and characterisation of stable metastatic variants

1984 • 61 citations

Quantitation of tumorigenic disseminating and arrested cancer cells

1984 • 57 citations

Different Deficiencies in the Prevention of Tumorigenic-Low-Metastatic Murine K-1735b Melanoma Cells From Producing Metastases<xref ref-type="fn" rid="FN2">2</xref>

1986 • 54 citations

Metastatic potential of B16 melanoma cells after in vitro selection for organ-specific adherence.

1985 • 51 citations

Analysis of tumour cell composition in tumours composed of paired mixtures of mammary tumour cell lines

1987 • 51 citations

Differential influence of organ site on three subpopulations of a single mouse mammary tumor at two distinct steps in metastasis

1991 • 50 citations

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice X. Immunoselection of tumor variants differing in tumor antigen expression and metastatic capacity

1980 • 47 citations

Quantitative selectivity of contact-mediated intercellular communication in a metastatic mouse mammary tumor line.

1983 • 46 citations

Differential effects of transforming growth factor beta 1 on the growth of poorly and highly metastatic murine melanoma cells.

1990 • 44 citations

G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.

1989 • 42 citations

In vivo and in vitro properties of malignant variants of RAW117 metastatic murine lymphoma/lymphosarcoma

1983 • 38 citations

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

1984 • 38 citations

Thein vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants

1989 • 37 citations

Metastatic Dissemination of B16 Melanoma: Pattern and Sequence of Metastasis<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1985 • 34 citations

Tumor subpopulation interactions affecting melphalan sensitivity in palpable mouse mammary tumors.

1991 • 28 citations

Therapeutic perturbation of the tumor ecosystem in reconstructed heterogeneous mouse mammary tumors.

1989 • 25 citations

Invasive activity, spreading on and chemotactic response to laminin are properties of high but not low metastatic mouse osteosarcoma cells.

1991 • 23 citations

Studies on clonal heterogeneity in two spontaneously metastasizing mammary carcinomas of recent origin

1985 • 22 citations

Evidence for metastatic heterogeneity of human renal cell carcinoma.

1988 • 21 citations

Lymphogenous and hematogenous metastasis of Lewis lung carcinoma in the mouse

1987 • 21 citations

Quantitative studies on cancer dissemination.

1969 • 19 citations

Spontaneous capillary tube migration of metastatic rat mammary adenocarcinoma cells.

1984 • 15 citations

Inhibition of lung colonization at two different steps in the metastatic sequence

1991 • 14 citations

Efficient recovery of clonogenic stem cells from solid tumors and occult metastatic deposits.

1990 • 13 citations

Effect of host immune status on the spontaneous metastasis of cloned cell lines of the 13762NF rat mammary adenocarcinoma

1985 • 11 citations

Centrifugal elutriation and characterization of tumor cells from venous blood of tumor-bearing mice: possible relevance to metastasis.

1984 • 11 citations

Clonal variation in the arrest, survival and growth of RIF-1 mouse sarcoma cells in the lungs of C3H mice

1983 • 7 citations

Contributions of vascularized lymph‐node metastases to hematogenous metastasis in a rat mammary carcinoma

1990 • 5 citations

Bioassay of circulating murine tumor cells: A comparison between intravenous and intramuscular inoculation on tumor incidence

1971 • 5 citations

New method to quantitate clonogenic tumor cells in the blood circulation of mice.

1983 • 5 citations

Tumor Cells Genetically Tagged with Transferred DNA Markers Reveal Evidence for Clonal Dominance of Primary Tumors by Metastatic Subpopulations

1989 • 3 citations