Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2005 • 2,369 citations

EMT and Dissemination Precede Pancreatic Tumor Formation

2012 • 1,950 citations

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

2009 • 1,676 citations

Regulation of immune responses by L-arginine metabolism

2005 • 1,636 citations

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 • 1,563 citations

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

2011 • 1,515 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion

2007 • 910 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

2011 • 801 citations

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

2008 • 758 citations

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

2012 • 641 citations

Myeloid-derived suppressor cell heterogeneity and subset definition

2010 • 617 citations

Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression

2007 • 613 citations

Hierarchy of immunosuppressive strength among myeloid‐derived suppressor cell subsets is determined by GM‐CSF

2009 • 542 citations

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

2010 • 541 citations

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

2010 • 538 citations

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

2006 • 531 citations

High-Dose Granulocyte-Macrophage Colony-Stimulating Factor-Producing Vaccines Impair the Immune Response through the Recruitment of Myeloid Suppressor Cells

2004 • 520 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

2011 • 481 citations

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

2010 • 469 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Role Of Immature Myeloid Cells in Mechanisms of Immune Evasion In Cancer

2005 • 352 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

CD11b+/Gr-1+ Immature Myeloid Cells Mediate Suppression of T Cells in Mice Bearing Tumors of IL-1β-Secreting Cells

2005 • 290 citations

Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells

2010 • 211 citations

Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF

2007 • 210 citations

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells

2009 • 206 citations

Cytokine Levels Correlate with Immune Cell Infiltration after Anti-VEGF Therapy in Preclinical Mouse Models of Breast Cancer

2009 • 185 citations

Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene

2011 • 185 citations

Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells

2011 • 157 citations

Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer

2008 • 147 citations

Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells

2006 • 133 citations

Overexpression of Interleukin-1β in the Murine Pancreas Results in Chronic Pancreatitis

2008 • 95 citations

A dual role for the immune response in a mouse model of inflammation-associated lung cancer

2011 • 87 citations

MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines

2009 • 56 citations