Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression

Inflammation and cancer

2002 • 14,174 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

2005 • 1,010 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Subverts Tumor Immunity toward a Type 2 Response

2007 • 795 citations

Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells

2007 • 718 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

The balance between IL-1 and IL-1Ra in disease

2002 • 694 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

1998 • 576 citations

Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma

2005 • 569 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

2006 • 531 citations

All-trans-Retinoic Acid Improves Differentiation of Myeloid Cells and Immune Response in Cancer Patients

2006 • 529 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

2004 • 458 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines.

1998 • 388 citations

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

1997 • 370 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

2007 • 317 citations

Immature myeloid cells and cancer-associated immune suppression

2002 • 304 citations

Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

1996 • 302 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

CD11b+/Gr-1+ Immature Myeloid Cells Mediate Suppression of T Cells in Mice Bearing Tumors of IL-1β-Secreting Cells

2005 • 290 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Resistance to Metastatic Disease in STAT6-Deficient Mice Requires Hemopoietic and Nonhemopoietic Cells and Is IFN-γ Dependent

2002 • 110 citations

Human squamous cell carcinomas of the head and neck chemoattract immune suppressive CD34+ progenitor cells

2001 • 81 citations

Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.

1990 • 71 citations

Profile Analysis of Variance as a Tool for Analyzing Correlated Responses in Experimental Ecology

1988 • 37 citations

Lessons from interleukin‐deficient mice: the interleukin‐1 system

2001 • 20 citations