Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

2010 • 5,069 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial

2002 • 1,711 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Consequences of Cell Death

2000 • 1,382 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer

2007 • 1,198 citations

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

2010 • 947 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Integrated data from 2 randomized, double‐blind, placebo‐controlled, phase 3 trials of active cellular immunotherapy with sipuleucel‐T in advanced prostate cancer

2009 • 791 citations

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity

2011 • 773 citations

6-Month Androgen Suppression Plus Radiation Therapy vs Radiation Therapy Alone for Patients With Clinically Localized Prostate Cancer

2004 • 767 citations

Is α/β for prostate tumors really low?

2001 • 622 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Preliminary Results of a Randomized Radiotherapy Dose-Escalation Study Comparing 70 Gy With 78 Gy for Prostate Cancer

2000 • 529 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 491 citations

Radical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy ≥72 Gy, permanent seed implantation, or combined seeds/external beam radiotherapy for stage T1–T2 prostate cancer

2003 • 463 citations

Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

2003 • 452 citations

Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity

2008 • 436 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 424 citations

Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

2005 • 373 citations

Combining radiotherapy and immunotherapy: A revived partnership

2005 • 349 citations

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

2009 • 302 citations

Two Listeria monocytogenes Vaccine Vectors That Express Different Molecular Forms of Human Papilloma Virus-16 (HPV-16) E7 Induce Qualitatively Different T Cell Immunity That Correlates with Their Ability to Induce Regression of Established Tumors Immortalized by HPV-16

2001 • 285 citations

In Vitro Generation of Human Cytotoxic T Lymphocytes Specific for Peptides Derived From Prostate-Specific Antigen

1997 • 267 citations

High Dose Rate Brachytherapy as Prostate Cancer Monotherapy Reduces Toxicity Compared to Low Dose Rate Palladium Seeds

2004 • 247 citations

Phase I Dose-Escalation Study of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer

2011 • 239 citations

Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV‐PSA) in patients with metastatic androgen‐independent prostate cancer

2002 • 230 citations

A simple analytic derivation suggests that prostate cancer α/β ratio is low

2001 • 184 citations

Is the α/β Value for Prostate Tumours Low Enough to be Safely Used in Clinical Trials?

2007 • 167 citations

Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.

1994 • 132 citations

A recombinant vaccinia virus expressing human prostate‐specific antigen (PSA): Safety and immunogenicity in a non‐human primate

1995 • 109 citations

Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.

2008 • 108 citations

Fusion to Listeriolysin O and Delivery by Listeria monocytogenes Enhances the Immunogenicity of HER-2/neu and Reveals Subdominant Epitopes in the FVB/N Mouse

2005 • 107 citations

Successful combination of local CpG‐ODN and radiotherapy in malignant glioma

2005 • 104 citations

Induction of human cytotoxic T lymphocytes specific for prostate-specific antigen

1997 • 99 citations

Cancer Immunotherapy Targeting the High Molecular Weight Melanoma-Associated Antigen Protein Results in a Broad Antitumor Response and Reduction of Pericytes in the Tumor Vasculature

2008 • 93 citations

Regulation of Tumor Growth by IFN-Γ in Cancer Immunotherapy

2001 • 90 citations

Development of a Listeria monocytogenes based vaccine against prostate cancer

2008 • 89 citations

Clinical utility of measurement free and total prostate-specific antigen (PSA): A review

1996 • 86 citations

Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox virus (alvac) cytokine gene delivery induces destruction of established prostate tumors

2001 • 84 citations

Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread

1992 • 82 citations

Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity

2004 • 82 citations

Long-Term Prognostic Significance of Primary Gleason Pattern in Patients With Gleason Score 7 Prostate Cancer: Impact on Prostate Cancer Specific Survival

2006 • 69 citations

The Spontaneous CD8+ T-Cell Response to HLA-A2-Restricted NY-ESO-1b Peptide in Hepatocellular Carcinoma Patients

2004 • 67 citations

CD4+CD25+ Regulatory T Cells That Secrete TGFβ and IL-10 Are Preferentially Induced by a Vaccine Vector

2004 • 65 citations

Construction and Characterization of an Attenuated Listeria monocytogenes Strain for Clinical Use in Cancer Immunotherapy

2008 • 63 citations

Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts

2008 • 60 citations

Risk of Prostate Cancer Recurrence in Men Treated With Radiation Alone or in Conjunction With Combined or Less Than Combined Androgen Suppression Therapy

2008 • 60 citations

Pillars article: development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. 1993. Science 260(5107): 547-549.

2008 • 55 citations

In the FVB/N HER-2/neu transgenic mouse both peripheral and central tolerance limit the immune response targeting HER-2/neu induced by Listeria monocytogenes-based vaccines

2006 • 52 citations

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

2006 • 49 citations

Point Mutation in Essential Genes with Loss or Mutation of the Second Allele

2001 • 47 citations

Prostate‐specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate‐targeted PSA/KLK2 double transgenic mice

2010 • 44 citations

Current Vaccination Strategies for Prostate Cancer

2011 • 42 citations

Immunotherapy and prostate cancer

2003 • 31 citations

Therapeutic cancer vaccines in cervical cancer: phase I study of Lovaxin-C.

2009 • 28 citations

Listeriolysin O is an improved protein carrier for lymphoma immunoglobulin idiotype and provides systemic protection against 38C13 lymphoma

2007 • 26 citations

Identification of an immunodominant H‐2D^b‐restricted CTL epitope of human PSA

2005 • 25 citations

Comparison of PSA-specific CD8+ CTL responses and antitumor immunity generated by plasmid DNA vaccines encoding PSA-HSP chimeric proteins

2004 • 18 citations

Irradiated Pancreatic Cancer Cells Undergo both Apoptosis and Necrosis, and Could Be Phagocytized by Dendritic Cells

2005 • 15 citations

The Prostate Specific Antigen: Its Use as a Tumor Marker for Prostate Cancer

1994 • 9 citations

Deleted Work

1955 • 0 citations