Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

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2004 • 11,755 citations

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

2004 • 11,620 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

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2008 • 1,993 citations

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

2009 • 1,676 citations

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

2008 • 1,597 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

Bioconductor: Open Software Development for Computational Biology and Bioinformatics

2007 • 884 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

2009 • 836 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

2010 • 801 citations

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

2006 • 798 citations

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

2009 • 732 citations

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

2009 • 706 citations

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β1

2009 • 702 citations

Myeloid-derived suppressor cell heterogeneity and subset definition

2010 • 617 citations

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

2007 • 614 citations

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

2010 • 598 citations

Hierarchy of immunosuppressive strength among myeloid‐derived suppressor cell subsets is determined by GM‐CSF

2009 • 542 citations

High-Dose Granulocyte-Macrophage Colony-Stimulating Factor-Producing Vaccines Impair the Immune Response through the Recruitment of Myeloid Suppressor Cells

2004 • 520 citations

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

2009 • 462 citations

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

2009 • 393 citations

Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells

2010 • 387 citations

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

2011 • 363 citations

Granulocyte colony-stimulating factor: Molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis

2008 • 360 citations

IL-17 Promotes Tumor Development through the Induction of Tumor Promoting Microenvironments at Tumor Sites and Myeloid-Derived Suppressor Cells

2010 • 313 citations

Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function

2007 • 309 citations

IL‐1β regulates a novel myeloid‐derived suppressor cell subset that impairs NK cell development and function

2010 • 293 citations

Reversal of Myeloid Cell–Mediated Immunosuppression in Patients with Metastatic Renal Cell Carcinoma

2008 • 278 citations

Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: Association with tumor-derived growth factors

2006 • 252 citations

Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma

2010 • 207 citations

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells

2009 • 206 citations

Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance

2005 • 205 citations

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils

2006 • 187 citations

Elevated Interleukin-6 and G-CSF in Human Pancreatic Cancer Cell Conditioned Medium Suppress Dendritic Cell Differentiation and Activation

2007 • 149 citations

Granulocyte colony-stimulating factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1+CD11b+ cells in cancer animal models

2005 • 98 citations

Altered Immune Function during Long-Term Host-Tumor Interactions Can Be Modulated to Retard Autochthonous Neoplastic Growth

2007 • 80 citations

A Case of Cervical Cancer with Aggressive Tumor Growth: Possible Autocrine Growth Stimulation by G-CSF and Il-6

2000 • 74 citations

Immune cell infiltration of primary and metastatic lesions: Mechanisms and clinical impact

2010 • 68 citations

Granulocyte Colony-Stimulating Factor/Granulocyte Colony-Stimulating Factor Receptor Biological Axis Promotes Survival and Growth of Bladder Cancer Cells

2007 • 65 citations

Myeloid derived suppressor cells in transplantation

2011 • 61 citations

Coexpression of granulocyte colony stimulating factor and its receptor in primary ovarian carcinomas

2001 • 58 citations

Myeloid‐derived suppressor cells – their role in haemato‐oncological malignancies and other cancers and possible implications for therapy

2011 • 55 citations

Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice

2009 • 51 citations

Granulocyte Colony-Stimulating Factor-Producing Carcinoma of Unknown Primary Site

2014 • 51 citations

Granulocyte-Colony Stimulating Factor-Producing Pancreatic Adenosquamous Carcinoma Showing Aggressive Clinical Course

2009 • 50 citations

Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells

2009 • 44 citations

Production of granulocyte colony-stimulating factor by head and neck carcinomas

1993 • 16 citations

Effect of the chimeric soluble granulocyte colony-stimulating factor receptor on the proliferation of leukemic blast cells from patients with acute myeloblastic leukemia.

1997 • 13 citations

Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells

2009 • 1 citations